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Activation of the RXR/PPARγ axis improves long-term outcomes after ischemic stroke in aged mice
Organization VETERANS HEALTH ADMINISTRATIONLocation PITTSBURGH, UNITED STATESPosted 1 Jan 2022Deadline 31 Dec 2025 ⚠️
VANIHUS FederalResearch GrantFY20253-methyl TTNEB9-cis-Retinoic Acid ReceptorAcuteAcute Brain InjuriesAdoptedAgingAgonistAnti-Cancer AgentsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsApicalApoplexyArbitratingArbitrationAttenuatedBexaroteneBiologicalBlood monocyteBody TissuesBrainBrain IschemiaBrain Nervous SystemBrain Vascular AccidentCNS InjuryCancer DrugCaringCause of DeathCell BodyCellsCellular Immune FunctionCerebral IschemiaCerebral StrokeCerebral cortexCerebrovascular ApoplexyCerebrovascular StrokeCerebrumChronicClinical TreatmentClinical TrialsCognitiveCulturing, in vitro Vertebrate, PrimaryDataDecision TreesDeteriorationDevelopmentDiagnosisDiseaseDisorderDistalDoseDrugsElderlyElectrophysiologyElectrophysiology (science)EncephalonEquilibriumEvolutionExhibitsFDA approvedFoundationsFunctional impairmentFundingFutureGatekeepingGene TranscriptionGenetic TranscriptionGliaGlial CellsGoalsGuidelinesHistologicHistologicallyHortega cellHospital AdmissionHospitalizationHyperactivityImmuneImmune responseImmune systemImmunesImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIn VitroInfiltrationInflammationInflammatoryInflammatory ResponseInjuryIntermediary MetabolismIschemic Brain InjuryIschemic EncephalopathyIschemic StrokeKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKolliker's reticulumLeftLong-term disabilityMacrophageMarrow monocyteMeasurementMedicationMetabolic ProcessesMetabolismMiceMice MammalsMicrogliaMiddle Cerebral Artery OcclusionModelingMolecularMurineMusMφNatureNeoplastic Disease Chemotherapeutic AgentsNerve CellsNerve FibersNerve UnitNervous System PhysiologyNeural CellNeurocyteNeurogliaNeuroglial CellsNeurologic DeficitNeurologic functionNeurologic outcomeNeurological functionNeurological outcomeNeuronsNeurophysiology / ElectrophysiologyNon-neuronal cellNonneuronal cellNull MouseOutcomeOxidation-ReductionPPAR gammaPPAR-gPPAR-γPPARgammaPPARγPeroxisome Proliferative Activated Receptor GammaPeroxisome Proliferator-Activated Receptor gammaPeroxisome Proliferator-Activated Receptor γPhagocytesPhagocytic CellPhagocytosisPharmaceutical PreparationsPhenotypePilot ProjectsPositionPositioning AttributePrimary Cell CulturesProductionProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqRXRRXR ProteinRecoveryRecovery of FunctionRedoxResearchResolutionRetinoic Acid Receptor RXRRetinoid X ReceptorsRoleSafetySolidStrokeSurvivorsTamoxifenTargretinTestingTherapeuticThiazolidinedione ReceptorTissuesTitrationsTranscriptionTumor-Specific Treatment AgentsVeteransadult animaladult youthadvanced ageafter strokeagedaged animalaged animalsaged miceaged mouseamebocyteangiogenesisanimal old ageanti-cancer drugattenuateattenuatesbalancebalance functionbehavior testbehavioral testbiologicbrain attackbrain repaircentral nervous system injurycerebralcerebral vascular accidentcerebrovascular accidentclinical interventionclinical relevanceclinical therapyclinical translationclinically relevantclinically translatableconditional knock-outconditional knockoutdevelopmentaldisabilitydrug/agentelderly animalelderly miceelectrophysiologicalfunctional outcomesfunctional recoverygatekeepergeriatricgitter cellglobal gene expressionglobal transcription profilegray matterhealinghost responseimmune functionimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vitro testingin vivoinjured CNSinjuriesinsightintraperitonealischemic brain damagelong-term recoverymature animalmesogliamicroglial cellmicrogliocytemilitary menmilitary womenmonocytenerve cementnervous system functionneural inflammationneuroinflammationneuroinflammatoryneuronalneuroprotectionneuroprotectivenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetold animalsold miceoxidation reduction reactionperivascular glial cellpilot studypost strokepoststrokepre-clinicalpreclinicalprimary outcomereceptor bindingreceptor boundrepairrepairedresolutionsresponsesenior citizensexsocial rolestroke modelstroke outcomestroke recoverystroke therapystroke treatmentstrokedstrokessubstantia albasubstantia griseatooltranscriptometranscriptome sequencingtranscriptomic sequencingtreating stroketrial regimentrial treatmentwhite matteryoung adultyoung adult ageyoung adulthood
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Description preview
Ischemic stroke is a leading cause of death and long-term disability in elderly veterans. It is well established that
post-stroke immune responses have a substantial impact on the progression of ischemic brain injury and brain
recovery, but there are no clinical treatments that successfully harness the restorative power of the immune
system while…
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