grant
Activation of androgen biosynthesis and drug metabolism by cytochrome b5
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 30 Sept 2009Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY202511-Decorticosterone17,20-Lyase21-Hydroxyprogesterone21-hydroxylase deficiencyAccelerationAcetatesActive SitesAeroseb-HCAndrogenic AgentsAndrogenic CompoundsAndrogensAnimalsAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsApplications GrantsBindingBinding SitesBiochemicalBiochemistryBiologicalBiological ChemistryBiophysical ProcessCancer DrugCetacortChemicalsChemistryChronicClinicalClinical TrialsCoenzyme IICombining SiteComplexConsumptionCort-DomeCortefCortenemaCortexoneCortisolCortisprayCortrilCouplingCysteineCytochrome P-450Cytochrome P-450 Enzyme SystemCytochrome P450Cytochrome P450 Family GeneCytochrome b-5CytochromesCytochromes b5DNA mutationDataDeoxycorticosteroneDependenceDermacortDesoxycorticosteroneDesoxycortoneDeuteriumDiseaseDisorderDoseDrug Metabolic DetoxicationDrug Metabolic DetoxificationDrug Side EffectsDrugsEldecortElectron TransportElectronsEndocrine Gland SecretionEnvironmentEnzymatic BiochemistryEnzyme GeneEnzymesEnzymologyEstrogensFerricytochrome b5Fluorescence SpectroscopyFruitGene ExpressionGenetic ChangeGenetic PolymorphismGenetic defectGenetic mutationGlucocorticoidsGoalsGrant ProposalsH elementH2 isotopeHalf-CystineHormonesHydrocortisoneHydrocortoneHydrogenHydroxylasesHydroxylationHydroxysteroidsHypertensionHytoneImpairmentIn VitroK elementKnowledgeL-CysteineLaboratoriesLeydig CellsLinkMalignant neoplasm of prostateMalignant prostatic tumorMedicalMedicationMetabolic Drug DetoxicationsMetabolism of Toxic AgentsMiceMice MammalsMineralocorticoidsMixed Function OxidasesMixed Function OxygenasesMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonooxygenasesMsecMurineMusMutationNAD phosphateNAD(H) phosphateNADH phosphateNADPNADPHNegative Beta ParticleNegatronsNeoplastic Disease Chemotherapeutic AgentsNicotinamide-Adenine Dinucleotide PhosphateNutracortP450PatientsPharmaceutical PreparationsPharmacologyPhosphatidesPhospholipidsPigmentsPlantsPolycystic Ovarian DiseasePolycystic Ovarian SyndromePolycystic Ovary SyndromePositionPositioning AttributePotassiumProcessProctocortProductionPropertyProstate CAProstate CancerProstate DiseaseProstate malignancyProstatic DiseasesReactionReactive SiteRegulationReproductionRiskSclerocystic Ovarian DegenerationSclerocystic Ovary SyndromeSeriesSpectroscopySpectrum AnalysesSpectrum AnalysisSteroid 17-HydroxylaseSteroid 17-alpha-monooxygenaseSteroid CompoundSteroidsTesticular Interstitial CellsTestosteroneTherapeutic AndrogenTherapeutic EstrogenTherapeutic HormoneTherapeutic TestosteroneTimeTrans-TestosteroneTriphosphopyridine NucleotideTumor-Specific Treatment AgentsVascular Hypertensive DiseaseVascular Hypertensive DisorderWomanXenobioticsabirateroneandrogen biosynthesisandrogen dependentandrogen excessandrogen responsiveandrogen sensitiveanti-cancer drugbiologicbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical mechanismbiophysical parametersbiophysical propertiescatalystchildbearing ageconformationconformationalconformational stateconformationallyconformationsdeclines in circulating testosteronedeclining testosteronedecreased levels of testosteronedecreases in testosteronedecreasing testosteronedeficiency in testosteronedesigndesigningdetoxificationdietary fruitdiminished testosteronedrug metabolismdrug/agentelectron transferexperimentexperimental researchexperimental studyexperimentsfertile agegenome mutationhigh blood pressurehuman diseasehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedin vivoinhibitorleydig interstitial celllow circulating testosteronelow levels of testosteronelower testosteronemalemale healthman's healthmenmen's healthmillisecondnanodiskpigmentpolycystic ovarypolycystic ovary diseasepolycystic ovary disorderpolymorphismprostate disorderreduced testosteronereduction in testosteronereproductive agereproductive yearsscaffoldscaffoldingside effecttestis interstitial celltestosterone declinetestosterone deficiencytestosterone insufficiencytestosterone losswasting♂
Description preview
Abstract
Cytochrome b5 (b5) profoundly influences the catalytic efficiency of many cytochrome P450-catalyzed
reactions, yet the mechanism(s) of this action of b5 on P450 enzymes are controversial. Among these b5-
regulated activities is the 17,20-lyase activity of P450 17A1 (steroid 17-hydroxylase/17,20-lyase), which is a key
step in the…
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