grant
Acetate and Endothelial Pathobiology
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 May 2023Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY2026ASCVDAcetatesAcetyl CoAAcetyl Coenzyme AAcetylationAnimal ModelAnimal Models and Related StudiesApoplexyArterial DisorderArterial Fatty StreakArteriopathyAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAtherosclerosisAtherosclerotic Cardiovascular DiseaseBlood VesselsBone-Derived Transforming Growth FactorBrain Vascular AccidentBypassCardiac infarctionCell Communication and SignalingCell SignalingCellular Metabolic ProcessCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicCitratesCytoplasmD-GlucoseDataDevelopmentDextroseDiseaseDisorderEndothelial CellsEndotheliumEnzyme GeneEnzymesEventFeedbackGEM modelGEMM modelGenerationsGenetically Engineered MouseGlucoseGoalsHypoxiaHypoxicIn VitroIn vivo analysisIntermediary MetabolismIntracellular Communication and SignalingLeiomyocyteLinkMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMesenchymalMetabolicMetabolic ActivationMetabolic ControlMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsMilk Growth FactorMitochondriaMurineMusMyocardial InfarctMyocardial InfarctionOralOxygen DeficiencyPaintPathologyPathway interactionsPeripheral AngiopathiesPeripheral Vascular DiseasesPeripheral Vascular DisorderPhosphorylationPhysiologicPhysiologicalPlatelet Transforming Growth FactorPlayPost-Transcriptional Gene SilencingPreventionProcessProductionProtein AcetylationProtein PhosphorylationPulmonary HypertensionPyruvatePyruvate Dehydrogenase ComplexRNA InterferenceRNA SilencingRNAiRegulationRoleS-acetate Coenzyme ASequence-Specific Posttranscriptional Gene SilencingSignal TransductionSignal Transduction SystemsSignalingSiteSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSourceStrokeTGF BTGF-betaTGF-βTGFbetaTGFβTechniquesTestingTherapeuticTherapeutic AgentsTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTranslatingTransplantationanaerobic glycolysisatheromatosisatherosclerosis plaqueatherosclerotic diseaseatherosclerotic lesionsatherosclerotic plaqueatherosclerotic vascular diseasebiological signal transductionbrain attackcardiac infarctcell metabolismcellular metabaolismcerebral vascular accidentcerebrovascular accidentchronic inflammationchronic inflammatory statechronic systemic inflammationclinical practicecoronary attackcoronary infarctcoronary infarctiondefined contributiondevelopmentaldriving forceefficacy testinggenetically engineered mouse modelgenetically engineered murine modelheart attackheart infarctheart infarctionin vitro testingin vivoin vivo evaluationin vivo testinginhibitorlong-term inflammationmitochondrialmodel of animalmouse modelmurine modelnano particlenano particle deliverynano-sized particlenanoparticlenanoparticle deliverednanoparticle deliverynanosized particlenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathwayperipheral blood vessel disorderpersistent inflammationplaques in atherosclerosispreventpreventingpulmonary arterial hypertensionpulmonary artery hypertensionpyruvate dehydrogenaseside effectsocial rolestrokedstrokessuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic evaluationtherapeutic targettherapeutic testingtherapeutically effectivetranslation strategytranslational approachtranslational strategytransplantvascularvascular inflammation
Description preview
Chronic vascular inflammation is a hallmark of atherosclerosis, pulmonary arterial
hypertension (PAH) and related conditions. It is also one of the principal causes of endothelial-
to-mesenchymal transition (EndMT). We have recently demonstrated that disruption of EndMT,
achieved by inhibiting endothelial-specific TGFβ signaling input, results in…
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