grant
A Vaccine for Lymphatic Filariasis, LFGuard™
Organization PAI LIFE SCIENCES, INC.Location SEATTLE, UNITED STATESPosted 1 Mar 2019Deadline 30 Nov 2027
NIHUS FederalResearch GrantFY202621+ years oldAdjuvantAdultAdult HumanAffectAgonistAlum AdjuvantAnimal ModelAnimal Models and Related StudiesAnimal TestingAntigensAssayBacteriaBancroftian ElephantiasisBioassayBiologic SciencesBiologicalBiological AssayBiological SciencesBioscienceBookletsBrochuresBrugia malayiChemistryChronicClinicalClinical ResearchClinical StudyClinical TrialsContracting OpportunitiesContractsCountryCoupledCulicidaeCyclic GMPDALYDevelopmentDiseaseDisorderDomestic RabbitDrug TherapyDrugsEffectivenessEndemic DiseasesEngineeringExperimental Animal ModelFilaria bancroftiFilaria sanguinis hominisFilarial ElephantiasesFormulationFutureGerbilsGrantGroups at riskGuanosine Cyclic MonophosphateHelminthsHomolog of Drosophila TOLLHumanIND FilingIND applicationIND packageIND submissionImmunityIncidenceIndividualInfectionInfection ControlInfectious AgentInterruptionInvestigational New Drug ApplicationInvestigatorsJirdLarvaLicensingLife SciencesLymph SystemLymphaticLymphatic FilariasisLymphatic NetworkLymphatic SystemLymphatic System Reticuloendothelial SystemLymphedemaM mulattaM. mulattaMacaca mulattaMacaca rhesusMedicationMerioneMiceMice MammalsModelingModern ManMorbidityMosquitoesMurineMusNational Institutes of HealthOryctolagus cuniculusPamphletsParasitesParasitic WormsPathologyPatientsPeople at riskPersonsPersons at riskPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhasePopulations at RiskPredispositionPreventative ImmunizationPreventative vaccinationPreventative vaccinePreventive ImmunizationPreventive vaccinationPreventive vaccineProphylactic immunizationProphylactic treatmentProphylactic vaccinationProphylactic vaccineProphylaxisProteinsProtocolProtocols documentationProtozoaProtozoalPublic HealthRabbitsRabbits MammalsRecombinant Fusion ProteinsReportingResearchResearch PersonnelResearch ResourcesResearchersResolutionResourcesRhesus MacaqueRhesus MonkeyRiskRodentRodent ModelRodentiaRodents MammalsRunningSBIRSafetySmall Business Innovation ResearchSmall Business Innovation Research GrantSterilitySusceptibilityTLR4TLR4 geneTechnologyTestingTherapeuticToll HomologueToxicologyTransmissionUnited States National Institutes of HealthVaccinesVirusWorld HealthWorld Health OrganizationWritingWuchereria bancroftiadulthoodalumaluminum sulfatebiologiccGMPcell bankchemotherapyclinical developmentcommunicable disease transmissiondesigndesigningdevelopmentaldisability-adjusted life yearsdisease classificationdisease transmissiondisorder classificationdrug detectiondrug interventiondrug testingdrug treatmentdrug/agentfirst in manfirst-in-humanfunctional mimicsglobal healthimmune response to vaccinationimmune response to vaccinesimmunogeninfectious disease transmissioninfectious organismlymph edemalymphatic edemamanufacturemodel of animalmortalityneglected tropical diseasesnon-compliancenon-compliantnon-human primatenoncompliancenoncompliantnonhuman primatenosologynovelpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphase 2 studyphase II studyphysical disabilityphysically disabledphysically handicappedpre-clinicalpreclinicalpreventpreventingprogramsprophylacticresolutionssteriletoll-like receptor 4transmission processvaccine associated immune responsevaccine candidatevaccine efficacyvaccine immune responsevaccine immunogenicityvaccine induced immune response
Description preview
PROJECT SUMMARY
Lymphatic filariasis (LF) is one of only a small number of diseases classified as potentially
eradicable. In 1997, the World Health Assembly passed a resolution to eliminate LF as a public
health problem and the approach involved yearly concurrent mass drug administration (MDA)
to the at-risk population in 52 countries. According…
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