grant
A translational approach to predicting small molecule drug permeation through microneedle-treated skin
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 10 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AffectAgeAge YearsAnimalsAreaBiologicalBlood PlasmaCaviaCharacteristicsChargeDevelopmentDosage FormsDoseDrug CompoundingDrug DeliveryDrug Delivery SystemsDrug KineticsDrug PreparationDrugsEnrollmentEnvironmentFormulationGoalsGuinea PigsGuinea Pigs MammalsHealthHumanHydrophobicityIn VitroKineticsKnowledgeLaboratoriesLengthMedicalMedicationMethodsMissionModern ManNIGMSNational Institute of General Medical SciencesNeedlesOralPathway interactionsPatientsPermeabilityPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacokineticsPharmacologic SubstancePharmacological SubstancePlasmaPlasma SerumPropertyResearchReticuloendothelial System, Serum, PlasmaRouteSkinStructureTestingTimeTranscutaneous AdministrationTransdermal AdministrationTransdermal Route of Drug AdministrationTransdermal substance administrationWorkabsorptionage associatedage correlatedage dependentage linkedage relatedage specificagesbiologicchemical propertyclinical applicabilityclinical applicationclinical relevanceclinically relevantcohortcost effectivedevelopmentaldrug/agentenrollhuman subjecthydrophilicityimprovedin vivoinnovateinnovationinnovativeionizationmicroporepathwaypharmaceuticalprogramssmall moleculetransdermal drug deliverytranslation strategytranslational approachtranslational strategy
Description preview
PROJECT SUMMARY / ABSTRACT
Transdermal drug delivery has many benefits including ease of product application for patients and more
consistent plasma drug concentrations compared to oral or IV dosing. However, many active pharmaceutical
ingredients (APIs) do not meet the strict physicochemical properties needed to permeate through the
hydrophobic…
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