grant
A tissue-based approach to understanding TB-associated lung fibrosis
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 3 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20262-dimensional3-D3-D Imaging3-Dimensional3D3D imagingAI systemAddressAfter CareAfter-TreatmentAftercareAlgorithmsAnatomic SitesAnatomic structuresAnatomyAntibiotics against tuberculosisAntitubercular AgentsAntitubercular AntibioticsArtificial IntelligenceAutoimmune DiseasesAutomobile DrivingBenchmarkingBest Practice AnalysisBody TissuesCause of DeathCell BodyCellsCessation of lifeClinicalComputer ReasoningCuesDeathDevelopmentDiseaseDisorderEpidemicFibrosing AlveolitisFibrosisFunctional impairmentFutureGoalsHIV disease statusHIV infection statusHIV serostatusHIV statusHIV1 infection statusHIV1 statusHealthHistopathologyHistoryHumanImageImmunofluorescenceImmunofluorescence ImmunologicImmunofluorescence MicroscopyImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIndividualInfectionInflammatoryInterventionKnowledgeLaboratoriesLeftLength of LifeLesionLongevityLungLung DiseasesLung ParenchymaLung Respiratory SystemLung TBLung TissueLung Tissue FibrosisLung TuberculosisLung damageM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMachine IntelligenceMacrophageMapsMedicalMetadataMiceMice MammalsMicroanatomyMicroscopic AnatomyMicroscopyModelingModern ManMolecularMorbidityMorphologyMurineMusMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφPathogenesisPathogenicityPathologicPathologic ProcessesPathological ProcessesPathologyPathway interactionsPersonsPreclinical TestingProcessPulmonary DiseasesPulmonary DisorderPulmonary FibrosisPulmonary TBPulmonary TuberculosisQOLQOL improvementQualifyingQuality of lifeRecording of previous eventsReportingResearch ResourcesResearch SpecimenResourcesSamplingSpecimenStructure of parenchyma of lungSurvivorsSymptomsSystemTB antibioticsTB infectionTB therapyTB treatmentTestingThree-Dimensional ImagingTimeTissue BanksTissue CollectionTissue repositoryTissuesTranslatingTuberculosisTuberculosis antibioticsTuberculostatic AgentsValidationVisualizationWorkanti-TBanti-tuberculosisantiTBantibiotic against TBassociated symptomautoimmune conditionautoimmune disorderautoimmunity diseasebenchmarkbiobankbiorepositorycandidate identificationco-morbidco-morbid symptomco-morbidityco-occuring symptomcomorbid symptomcomorbidityconcurrent symptomcooccuring symptomdevelopmentaldiffuse interstitial pulmonary fibrosisdisease of the lungdisorder of the lungdisseminated TBdisseminated tuberculosisdrivingfibrogenesisfibrosis in the lungfibrotic lung diseasefibrotic pulmonary diseasegenetic approachgenetic strategyhistorieshuman tissueidiopathic pulmonary fibrosisimagingimaging approachimaging based approachimprovedimprovements in QOLimprovements in quality of lifeinfection due to Mycobacterium tuberculosisinjury and repairinjury to tissueinsightlung disorderlung fibrosislung functionlung healthlung injurymeta datamortalitymouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypost treatmentpre-clinical testingpreventpreventingpulmonary damagepulmonary functionpulmonary healthpulmonary injurypulmonary tissue damagepulmonary tissue injuryquality of life improvementsmall moleculespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssymptom associationsymptom comorbiditythree dimensionaltissue injurytooltreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathytwo-dimensionalvalidations
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Description preview
Post-TB lung disease (PTLD) contributes substantially to the overall morbidity and mortality associated with TB
infection. On a histopathological level, fibrosis is a significant feature of PTLD and likely underpins many
associated symptoms and clinical findings. Adjunctive therapies that could be used with traditional anti-TB
antibiotics to…
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