grant
A role for pharmaceutical control of protease-activated receptor-2 for the treatment of asthma
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 16 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldARRB2AcuteAdultAdult HumanAfferent NeuronsAirway Hyper-responsivenessAllergensAllergic asthmaAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnimalsAnodynesAntinociceptive AgentsAntinociceptive DrugsAsthmaBiological AgentBiological ProductsBronchial AsthmaCaringCell Communication and SignalingCell SignalingChildChild YouthChildren (0-21)ChronicClinical TrialsCockroachesComplementComplement ProteinsDevelopmentDictyopteraDiseaseDisorderDorsal Root GangliaDrugsEpithelial CellsEpitheliumEsteroproteasesExposure toExtracellular Signal-Regulated Kinase GeneExtrinsic asthmaG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGrantHumanImmune responseIn VitroIndividualInflammationInflammatoryIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLigandsLung DiseasesMAP Kinase GeneMAPKMAPK Signaling PathwayMAPK Signaling Pathway PathwayMediatingMedicationMiceMice MammalsMitogen-Activated Protein Kinase GeneModelingModern ManMucous body substanceMucusMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNociceptorsNodose GanglionNull MouseOrgan DonorPAR-2 ReceptorPAR2 ReceptorPathway interactionsPatientsPeptidasesPeptide HydrolasesPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhysiologicPhysiologicalPopulationPre-Clinical ModelPreclinical ModelsPrevalenceProductionProtease GeneProtease-Activated Receptor 2ProteasesProteinase Activated Receptor 2ProteinasesProteolytic EnzymesPulmonary DiseasesPulmonary DisorderReportingRespiratory DiseaseRespiratory EpitheliumRespiratory Signs and SymptomsRespiratory System DiseaseRespiratory System DisorderRoleSensory NeuronsSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedSpinal GangliaStructure of respiratory epitheliumSymptomsSyndromeTestingTherapeuticTrypsin ReceptorUnited StatesValidationadulthoodairway epitheliumairway hyper-reactivityairway hyperactivityairway hyperreactivityairway hyperresponsivenessairway hypersensitivityairway symptomallergen responseallergic responseallergy responseantagonismantagonistarrestin Basthma modelasthma patientasthmaticasthmatic patientatopic asthmaaxon signalingaxon-glial signalingaxonal signalingbeta-arrestinbeta-arrestin 2biological sex as a modifierbiological signal transductionbiologicsbiopharmaceuticalbiotherapeutic agentcellular targetingcomplementationcostcytokinedevelopmentaldisease of the lungdisorder of the lungdorsal root gangliondrug/agentdust miteefficacy testingenvironmental allergenexperimentexperimental researchexperimental studyexperimentsextrinsic allergic asthmafungusglia signalingglial signalinghost responseimmune system responseimmunoresponseimprovedin vitro Modelin vivoin vivo Modelkidslung disordermouse modelmucousmurine modelnerve signalingneural signalingneuronalneuronal signalingneurotransmissionnew approachesnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnociceptive neuronsnovelnovel approachesnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpain killerpain medicationpain modelpain relieverpain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspainkillerpathwaypharmaceuticalpharmacologicpre-clinicalpreclinicalpyroglyphidrespiratory symptomrespiratory tract epitheliumresponsesex as a biological factorsex as a biological measuresex as a biological risk factorsex as a biological variablesex as a biological variancesex as a biologically significant variablesex as a fundamental variableside effectsmall moleculesocial rolevalidationsyoungsterβ-arrestin
Description preview
PROJECT ABSTRACT
Asthma is a heterogenous disease that impacts ~10% of the US population. It presents as a syndrome of non-
specific airway hyperresponsiveness, inflammation and intermittent respiratory symptoms. Even though more
than half of patients receiving standard asthma medication remain uncontrolled, mainstay treatments have been
largely…
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