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A Rhesus Macaque Model of HIV and HBV co-infection
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 20 Mar 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdenoviridaeAdenovirusesAdolescentAdolescent YouthAdultAdult HumanAfrica South of the SaharaAnimal ModelAnimal Models and Related StudiesAnimalsBloodBlood Reticuloendothelial SystemBlood SerumBody TissuesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCause of DeathCell BodyCell Surface AntigensCellsChimpChimpanzeeChronicChronic Hepatitis BCircular DNAClinicalCodonCodon NucleotidesDNADNA TherapyDeoxyribonucleic AcidDucksEnsureFrequenciesGene Transfer ClinicalGenetic InterventionGenomeGenomicsHBVHBV AcquisitionHBV GenotypeHBV Liver DiseaseHBV infectionHIVHIV InfectionsHIV and HBVHIV and hepatitis BHIV-HBVHIV/HBVHIV/hepatitis BHIV/hepatitis B virusHTLV-III InfectionsHTLV-III-LAV InfectionsHealthHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatitis B AcquisitionHepatitis B InfectionHepatitis B VirusHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsImmuneImmunesImmunological Surface MarkersImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInfectionIntravenousLAV-HTLV-IIILiverLiver CellsLiver Cells CarcinomaLiver DysfunctionLiver FibrosisLiver diseasesLiver lesion biopsyLong-term infectionLymphadenopathy-Associated VirusM mulattaM. mulattaMacacaMacaca mulattaMacaca rhesusMacaqueMarmota monaxMiceMice MammalsModelingModern ManMonitorMurineMusNHP modelsPathogenesisPatientsPersonsPhysiologicPhysiologicalPositionPositioning AttributePrealbuminPrevalencePrimary carcinoma of the liver cellsPrimatesPrimates MammalsProalbuminProbabilityReceptor ProteinRegimenResearchRhesus MacaqueRhesus MonkeyRouteSIVSamplingSerotypingSerumSimian Immunodeficiency VirusesSoutheast AsiaSoutheastern AsiaStructureSub-Saharan AfricaSubsaharan AfricaSurface AntigensT cell responseT-CellsT-LymphocyteT8 CellsT8 LymphocytesTaurine CholateTaurocholateTechniquesTeff cellTestingTimeTissuesTransgenic OrganismsTransmissionTransplantationTransthyretinViral BurdenViral LoadViral Load resultViral VectorViremiaVirionVirusVirus ParticleVirus-HIVWoodchuckWorkacute infectionadulthoodchallenge in rhesus macaqueschronic HBV infectionchronic hepatitis B infectionchronic hepatitis B virus infectionchronic infectionchronic infections with hepatitis B viruschronically infected with HBVchronically infected with hepatitis Bco-infectioncohortcoinfectionconstrictiondesigndesigningeffector T cellexhaustionexperiencefibrotic livergene manipulationgene repair therapygene therapygene-based therapygenetic manipulationgenetic therapygenetically manipulategenetically perturbgenomic therapyglobal healthground hoghepatic body systemhepatic diseasehepatic fibrosishepatic organ systemhepatitis B viral infectionhepatitis B virus acquisitionhepatitis B virus and human immunodeficiency virushepatitis B virus genotypehepatitis B virus infectionhepatitis B virus liver diseasehepatopathyhigh riskhypoimmunityimmune deficiencyimmune suppressionimmune suppressive activityimmune suppressive functionimmunodeficiencyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivoinfected rhesus macaquesinfected rhesus monkeyinfected with HBVinfected with hepatitis Binfected with hepatitis B virusinfection in rhesus macaquesinfection of rhesus macaquesinfection with HBVinfection with hepatitis B virusjuvenilejuvenile humanliver biopsyliver carcinomaliver disordermodel of animalnonhuman primate modelsnovelpersistent infectionpolypeptidepreventpreventingpromoterpromotorreceptorrhesus challengerhesus macaque challengerhesus monkey infectionthymus derived lymphocytetransgenictransmission processtransplantvectorviraemiaviral sepsisvirusemia
Applications closed.
Description preview
PROJECT SUMMARY
HIV and HBV are both recognized as major global health concerns. HIV infects 37 million people worldwide,
while HBV infects 257 million. HIV/HBV co-infection is common due to highly similar routes of transmission, with
an estimated 10% of HIV-infected individuals also infected with HBV. In addition to their similar sexual and…
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