grant
A Novel, Multi-compartment Intravaginal Ring for Prevention of Genital Herpes and Unintended Pregnancy
Organization OAK CREST INSTITUTE OF SCIENCELocation MONROVIA, UNITED STATESPosted 10 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20253,5 cyclic AMP synthetaseAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdenyl CyclaseAdenylate CyclaseAdenylyl CyclaseAdherenceAdoptedAffinityAnti-viral AgentsAnti-viral TherapyAssayBioassayBiochemicalBiological AssayBiologyCharacteristicsChemicalsChemistryClinicalClinical TrialsCoitusCollaborationsContraceptionContraceptive AgentsContraceptive methodsContraceptivesCoupledCouplingDataDevelopmentDiseaseDisorderDoseDrug CombinationsDrug DeliveryDrug Delivery SystemsDrug InteractionsDrug KineticsDrugsEffectivenessEndocrine Gland SecretionEnsureEnzyme GeneEnzymesEpidemicEvaluationExcipientsFertility ControlFertilization in VitroFertilized EggFertilized OvumFormulationGenital Herpes SimplexGenital OrgansGenitaliaGoalsHHV-2HHV2HIVHPVHSVHSV-1HSV-2HSV1HSV2Health BenefitHerpes GenitalisHerpes SimplexHerpes Simplex InfectionsHerpes Simplex Type 1Herpes Simplex VirusHerpes Simplex Virus 1Herpes Simplex Virus 2Herpes Simplex Virus Type 1Herpes Simplex Virus Type 2Herpes labialis VirusHerpes simplex diseaseHerpesvirus 1Herpesvirus 2 (alpha), HumanHerpesvirus hominis diseaseHerpesvirus progenitalisHigh Risk WomanHormonesHumanHuman (alpha) herpes virus 2Human Herpesvirus 2Human Immunodeficiency VirusesHuman Papilloma VirusHuman PapillomavirusHuman herpes simplex virus type 2HybridsIn VitroIndividualInfectionInfectious Human Wart VirusInhibition of FertilizationIntravaginal AdministrationInvestigatorsKnowledgeLAV-HTLV-IIILeadLesionLibrariesLymphadenopathy-Associated VirusMedicationMembraneMethodsMiceMice MammalsModalityModern ManMultipurpose prevention technologyMurineMusOocytesOralOvineOvisOvocytesPK/PDPathogenesisPb elementPeptidesPeriodicalsPharmaceutical PreparationsPharmacokineticsPharmacologyPrEPPre-Clinical ModelPreclinical ModelsPreventionPrevention therapyProcessPropertyPublic HealthRegimenResearchResearch PersonnelResearchersRiskSafetySexual IntercourseSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionSheepSimplexvirusSpermSperm MotilitySpermatozoaTechnologyTest-Tube FertilizationTestingTherapeutic HormoneTopical Drug AdministrationTopical applicationTranslationsTransmissionUlcerUlcerationUnplanned pregnancyUser ComplianceVaccinesVaginaVaginal AdministrationVaginal Drug AdministrationVaginal GelVaginal InstillationsVaginal JelliesVaginal RingVaginal Route of Drug AdministrationVaginal deliveryVaginal delivery procedureVenereal DiseasesVenereal DisordersVenereal InfectionsViralVirusVirus-Genital HerpesVirus-HIVWomananti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsapply topicallyapply vaginallyat-risk femalesat-risk womenavoid pregnancychildbearing agecontraceptive targetdeliver topicallydeliver vaginallydesigndesigningdevelopmentaldrug release kineticsdrug release ratedrug/agentexperiencefemale genital tractfemale reproductive tractfemales at high riskfertile agegenital herpesheavy metal Pbheavy metal leadherpes genitaliaherpes simplex iherpes simplex iiherpes simplex virus 1 infectionherpes simplex virus infectionherpes simplex-1high risk femaleshuman alphaherpesvirus 2improvedin vivoinhibitorinnovateinnovationinnovativeinterestintravaginal applicationintravaginal ringlead candidatemale fertilitymembrane structuremetermicrobe pathogenmicrobial pathogenmultipurpose preventionnext generationnovelpathogenic microbeperiodicperiodicalpharmacokinetics and pharmacodynamicspharmacologicpre-clinicalpre-exposure prophylaxispreclinicalpreventpreventingprototypereproductivereproductive agereproductive yearsresidenceresidential buildingresidential sitescale upsexsexually acquired infectionsite targeted deliverysmall molecular inhibitorsmall moleculesmall molecule inhibitorsperm cellsperm functionsperm mobilitysuccesstargeted deliverytopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttranslationtransmission processtreat topicallyunintended pregnancyuptakevaginal applicationvaginal drug deliveryvaginal fluidvenereal herpesviral infectious disease treatmentviral transmissionvirus transmissionwart viruswomen at high riskwomen's genital tractwomen's reproductive tractzoospermzygote
Description preview
ABSTRACT
Genital herpes simplex virus (HSV) infection is one of the most common sexually transmitted infections
worldwide. The infection is lifelong: there currently is no cure and no vaccine. In addition, HSV-1 and -2,
human papillomavirus (HPV), and human immunodeficiency virus (HIV) are responsible for intersecting
epidemics, where the disease…
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