grant
A Novel Metabolic Pathway Regulates Urinary Tract Infections in the Bladder
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 24 Sept 2014Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20250-11 years oldAffectAffinityAnimalsAssayAstronomyAutoradiographyAutoregulationBackBacteriaBiliverdinBiliverdineBioassayBiological AssayBiologyBiomedical EngineeringBladderBladder Transitional Cell EpitheliumBladder Urinary SystemBladder UrotheliumBladder mucosaCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCarbon MonoxideCarrier ProteinsCas nuclease technologyCell BodyCell divisionCellsChelating AgentsChelatorsChemicalsChemistryChildChild YouthChildren (0-21)CirculationCitratesClinicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommunicationComplexComplexonsCongenital Genitourinary AbnormalityCrystallographiesCrystallographyCytolysisDNA ReplicationDNA SynthesisDNA biosynthesisDNA metabolismDNA mutationDataDehydrobilirubinDorsumDrug Metabolic DetoxicationDrug Metabolic DetoxificationDuctDuct (organ) structureEndocytic VesicleEndocytotic VesicleEnterobactinEnterochelinEnzyme GeneEnzymesEpithelial CellsEpitheliumEventEvolutionFe chelationFe elementFerroprotoporphyrinGene DeletionGeneralized GrowthGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenitourinary DiseasesGrowthHematuriaHemeHeme IronHomeostasisHumanHydrogen OxideImaging DeviceImaging InstrumentImaging ToolImmuneImmunesInfectionIntermediary MetabolismInvadedIronIron ChelatesIron Chelating AgentsIron ChelationIron chelatorK pneumoniaeK. pneumoniaeKO miceKidneyKidney Urinary SystemKlebsiella pneumoniaeKnock-out MiceKnockout MiceLCN2LCN2 geneLipocalin 2LysisMammaliaMammalsMeasuresMediatingMedicineMetabolicMetabolic Drug DetoxicationsMetabolic PathwayMetabolic ProcessesMetabolismMetabolism of Toxic AgentsMetalsMethodsMiceMice MammalsMicrobeModern ManMucosaMucosal TissueMucous MembraneMurineMusMutationNGALNatureNeutrophil Gelatinase-Associated LipocalinNon-Polyadenylated RNANull MouseNutrientNutritionalNutritional ImmunityOncogenic Lipocalin 24P3OoecyanOrganOrganismP mirabilisP. mirabilisPathway interactionsPatientsPhasePhosphatesPhysiologicPhysiologicalPhysiological HomeostasisPlayProcessProductionProductivityProstateProstate GlandProstatic GlandProteinsProteus mirabilisProtohemePublicationsRNARNA Gene ProductsRadioautographyReporterRibonucleic AcidRoleScienceScientific PublicationScientistSeriesSiderochromesSiderophilinSiderophoresSourceSpecialistStealingSystemTestingTheftTimeTissue GrowthToxic effectToxicitiesTransferrinTransport Protein GeneTransport ProteinsTransporter ProteinUreterUrethraUrinary tractUrinary tract infectionUrinary tract infectious diseaseUrineUrogenital AbnormalitiesUrogenital DiseasesUrologyUrothelial CellUrotheliumUterocalinUteroverdineVisitWaterWomanWorkapical membranebio-engineeredbio-engineersbioengineeringbiological engineeringchelationcircadian clockcircadian pacemakerdetoxificationexperimentexperimental researchexperimental studyexperimentsferrohemegene deletion mutationgenitourinary tractgenome mutationhost microbe associationhost microbe relationshiphost-microbe interactionshost-microbial interactionshost-microorganism interactionsin vivoinjury responseinorganic phosphateinventionkidsliving systemnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnutritiousontogenypathwaypharmacologicpressurepreventpreventingrenalresponseresponse to injurysmall moleculesocial rolespace sciencetooltraffickingurethralurinaryurinary bladderurinary infectionurogenital tractyoungster
Description preview
PROJECT 3: PROJECT SUMMARY/ABSTRACT
Urinary tract infections are the most common urogenital abnormality worldwide affecting multiple organs of the
urinary tract including the urethra, bladder, prostate, ureter, and kidney. To establish a urinary tract infection,
bacteria must obtain nutrients in order to undergo continuous replication. These…
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