grant
A Novel Imaging Strategy to Optimize Brain Tumor Immunotherapy
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AddressAdoptive Cell TransfersAffinityAntibodiesAntibody FragmentsAttentionBBB crossingBenchmarkingBest Practice AnalysisBindingBiochemicalBiodistributionBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain CancerBrain GlioblastomaBrain Glioblastoma MultiformeBrain MetastasisBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCD8CD8BCD8B1CD8B1 geneCNS Nervous SystemCNS TumorCNS neoplasmCancersCell BodyCell DeathCell-Mediated Lympholytic CellsCellsCentral Nervous SystemCentral Nervous System NeoplasmsCentral Nervous System TumorsCervical Lymph NodeCervical lymph node groupChildhood Brain NeoplasmChildhood Brain TumorClinicalClinical ResearchClinical StudyClinical TrialsCytolytic T-CellCytoplasmic GranulesCytotoxic T CellCytotoxic T-LymphocytesCytotoxic cellDetectionDevelopmentDisease ManagementDisorder ManagementEffectivenessEncephalonEvaluationExocytosisF elementFluorineGlioblastomaGlycoproteinsGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrade IV Brain Astrocytic NeoplasmGrade IV Brain Astrocytic TumorGrade IV Brain AstrocytomaGranzymeHemato-Encephalic BarrierHistologyHumanImageImmuneImmune TargetingImmune mediated therapyImmune responseImmune systemImmunesImmunocompetentImmunoglobulin FragmentsImmunologically Directed TherapyImmunotherapyInflammationInvestigatorsK lymphocyteKO miceKnock-out MiceKnockout MiceLYT3LibrariesLymphatic cellLymphocyteLymphocyticMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicinal ChemistryMetabolicMetastatic Neoplasm to the BrainMetastatic Tumor to the BrainMetastatic malignant neoplasm to brainMethodologyMethodsMiceMice MammalsModelingModern ManMolecular InteractionMonitorMurineMusNK CellsNMR ImagingNMR TomographyNatural Killer CellsNatureNeuraxisNuclear Magnetic Resonance ImagingNull MouseOrganPETPET ScanPET imagingPETSCANPETTPathway interactionsPatient CarePatient Care DeliveryPatient SelectionPatientsPenetrancePenetrationPeptidesPharmaceutic ChemistryPharmaceutical ChemistryPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPreclinical dataProteinsRad.-PETRadiolabeledResearchResearch PersonnelResearchersResistanceRodentRodentiaRodents MammalsSolid NeoplasmSolid TumorStructureT cell infiltrationT-CellsT-LymphocyteT-Lymphocyte and NK-CellT-Lymphocyte and Natural Killer CellTM-MKRTestingTherapeuticTimeTranslationsTreatment Side EffectsTreatment-related side effectsTumor MarkersVaccinesValidationVisualizationWild Type MouseWorkZeugmatographyadoptive cell therapyadoptive cellular therapyanti-tumor immune therapyanti-tumor immunotherapybenchmarkblood-brain barrier crossingbloodbrain barrierbloodbrain barrier crossingbrain micrometastasiscancer cellcancer microenvironmentcancer progressioncare for patientscare of patientscaring for patientscheck point blockadecheckpoint blockadeclinical developmentcontrast enhanceddevelop therapydevelopmentalearly biomarkersearly detection biomarkersearly detection markersglioblastoma multiformeglioblastoma multiforme brain tumorsgranulehost responseimagingimaging agentimaging probeimmune check point blockadeimmune checkpoint blockadeimmune competentimmune microenvironmentimmune modulating strategyimmune modulatory strategyimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunomodulatory strategyimmunoresponseimmunosuppressedimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedin vivoinsightintervention developmentkiller T celllipophilicitylymph celllymph organlymphatic organlymphocyte pore-forming proteinlymphoid organmalignancymouse modelmurine modelnecrocytosisneoplasm immunotherapyneoplasm progressionneoplasm/cancerneoplastic progressionnew approachesnovelnovel approachesnovel strategiesnovel strategyoutcome predictionpathwaypediatric brain neoplasmpediatric brain tumorperforinpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypreclinical findingspreclinical informationpreventpreventingquantitative imagingradiolabelradiolabelingradiolabelsradioligandradiologically labeledradiotracerresistantresponseresponse to therapyresponse to treatmentsmall moleculespatial and temporalspatial temporalspatiotemporalspongioblastoma multiformesuccesstherapeutic responsetherapy developmenttherapy responsethymus derived lymphocytetranslationtreatment developmenttreatment responsetreatment responsivenesstumortumor biomarkertumor immune microenvironmenttumor immune therapytumor immunotherapytumor microenvironmenttumor of the central nervous systemtumor progressiontumor specific biomarkertumor-immune system interactionstumors in the braintumors in the central nervous systemunnecessary treatmentuptakevalidationswildtype mouse
Description preview
ABSTRACT.
Immunotherapy has emerged as a successful therapeutic strategy for a variety of cancers. The recent success
of immunotherapies in other solid tumors has sparked increased attention to treatments targeting the immune
system in glioblastoma (GBM) and other brain cancers. One of the key challenges in the successful treatment
of brain tumors…
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