grant
A Multisystem Resilience Approach in the Assessment of Postsurgical Pain Trajectories
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 14 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAffectAgeArthritisArthroplastyBehavioralBiologicalCharacteristicsChronicChronic disabling painChronic low back painConsensusCoxaDegenerative ArthritisDegenerative polyarthritisDevelopmentDimensionsEmotional DepressionExhibitsGoalsHealthHealth Care UtilizationHipHip Prosthesis ImplantationHip region structureIndividualInterventionInvestigationJoint Prosthesis ImplantationJointsKneeKnee arthroplastyKnee joint replacement operationKnee replacementKnowledgeLiteratureLong-term painMeasuresMental DepressionModalityModelingNatureObservation researchObservation studyObservational StudyObservational researchOperative ProceduresOperative Surgical ProceduresOrthopedic ProceduresOrthopedic SurgeryOsteoarthritisOsteoarthrosisOutcomePainPainfulPatientsPatternPerioperativePersistent painPersonsPhenotypePhysical FunctionPopulationPost-operative PainPostoperativePostoperative PainPostoperative PeriodPrecision Medicine InitiativePrediction of Response to TherapyPredictive FactorProceduresProcessPsychosocial FactorRecoveryRefractoryReplacement ArthroplastyResearchResearch ResourcesResourcesRisk FactorsRoleSamplingSeveritiesSiteSocial supportSociologySourceStressSurgicalSurgical InterventionsSurgical ProcedureSymptomsSystemTechniquesTheoretic ModelsTheoretical modelTimeTotal Knee ReplacementUnited StatesWorkadulthoodagesarthriticbiologicbuild resiliencebuild resiliencychronic painchronic pain conditionchronic pain disorderchronic painful conditioncognitive functionconstant paindecrease resiliencedecrease resiliencydegenerative joint diseasedepressiondepression symptomdepressivedepressive symptomsdevelop resiliencedevelop resiliencydevelopmentaldisabilityenhance resilienceenhance resiliencyexperiencefacilitate resiliencefunctional disabilityglobal healthhealth care service usehealth care service utilizationhip arthroplastyhip joint replacementhip replacementhip replacement arthroplastyhypertrophic arthritisimprove resilienceimprove resiliencyimprovedincrease resilienceincrease resiliencyindividual patientinnovateinnovationinnovativeinsightjoint arthroplastyjoint replacementknee replacement arthroplastylasting painlower resiliencelower resiliencynovelolder adultolder adulthoodon-going painongoing painopiate consumptionopiate drug useopiate intakeopiate useopioid consumptionopioid drug useopioid intakeopioid useoptimismpain adaptationpain after surgerypain catastrophizingpain modelpain reliefpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespositive attitudepost-surgical painpostoperative recoverypostsurgical painprecision medicineprecision-based medicinepredict therapeutic responsepredict therapy responsepromote resiliencepromote resiliencyprospectiveprotective effectprotective factorspsychologicpsychologicalpsychosocial variablesrecovery after surgeryrecovery following surgeryrelieve painresilienceresilience developmentresilience factorresiliency factorresilientresponseresponse to therapyresponse to treatmentrisk stratificationsocialsocial rolesocial support networkstratify risksuccesssurgerysymptomatologytherapeutic agent developmenttherapeutic developmenttherapeutic responsetherapy predictiontherapy responsetooltotal knee arthroplastytraittreatment predictiontreatment responsetreatment response predictiontreatment responsiveness
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PROJECT SUMMARY/ABSTRACT
Osteoarthritis affects approximately 30 million people in the United States and is the leading cause of pain and
disability among older adults. Total joint arthroplasty (TJA) is among the most common elective surgery for
patients with refractory knee and hip arthritis. Although a proportion of patients achieve benefits…
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