grant

A mixed methods pre-implementation study of a trauma-informed care intervention for hospitalized patients with serious illness

Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2025Deadline 31 Oct 2027
NIHUS FederalResearch GrantFY202521+ years oldActive Follow-upAcuteAddressAdultAdult HumanAdvisory CommitteesAgingAnxietyApplication ContextCaringClinicalClinical TrialsConsolidated Framework for Implementation ResearchConsolidated Framework for Implementation ScienceConsolidated Framework for Implementing ChangeDataData CollectionDepersonalizationDoctor's DegreeDoctorate DegreeEffectivenessEnsureEnvironmental FactorEnvironmental Risk FactorEthicistsEthics ConsultantsFeasibility StudiesFutureGenderGoalsGuidelinesHealth CareHospital AdmissionHospitalistsHospitalizationHospitalsIllness impactIndividual National Research Service AwardInstitutionInterventionInterviewInvestigatorsKnowledgeMapsMeasuresMentorshipMethodsModelingNIH National Research Service Award for IndividualNRSANational Institute of AgingNational Institute on AgingNational Research Service AwardsNatureNursesOutcomePainPainfulPalliative CarePalliative TherapyPalliative TreatmentPatient CarePatient Care DeliveryPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPennsylvaniaPerceptionPersonsPhysiciansPopulationPreparationProcessPsychosocial Assessment and CarePublishingQOL improvementRaceRacesRecurrenceRecurrentResearchResearch MethodologyResearch MethodsResearch PersonnelResearch ProposalsResearch SupportResearchersRoleSamplingScienceShapesSocial WelfareSocial WorkersSourceSpecialistSpiritualityStructureSurvey InstrumentSurveysSymptomsTask ForcesTestingTrainingTraumaTreatment EfficacyUniversitiesWorkWritingacceptability and feasibilityactive followupacute careadulthoodadvisory teamcare deliverycare for patientscare of patientscare utilizationcareercaring for patientsco-morbidco-morbiditycomfort carecomorbiditycontextual factorsdesigndesigningdoctoral degreeenvironmental riskexperiencefollow upfollow-upfollowed upfollowuphealth care settingshospital careimplementation scienceimplementation studyimprovements in QOLimprovements in quality of lifeinsightintervention designintervention efficacylife spanlifespannovelnurseolder adultolder adulthoodpalliative interventionpatient oriented outcomespilot testpost-trauma stresspost-traumatic stresspost-traumatic stress symptomspost-traumatic symptomsposttrauma stressposttraumatic stressposttraumatic stress symptomsposttraumatic symptomspre-docpre-doctoralpreparationspreventpreventingpsychologicpsychologicalpsychosocialpsychosocial assessmentpsychosocial carepsychosocial studiespsychosocial supportquality of life improvementracialracial backgroundracial originresearch and methodsresponseskillssocial health determinantssocial roletherapeutic efficacytherapy designtherapy efficacytreatment design
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Full Description

Nearly two-thirds of adults living with serious illness also experience posttraumatic stress symptoms (PTSS). PTSS and serious illness impacts older adults as a result of cumulative hardships across the lifespan. Particularly during acute hospital care, patients with comorbid serious illness and PTSS experience higher rates of pain and anxiety, and longer hospitalizations. Despite national palliative care guidelines that recognize the importance of addressing trauma during care delivery, there is little evidence regarding the effectiveness of current trauma- informed interventions that target reduced retraumatization during hospitalization for serious illness care. Lack of knowledge regarding intervention context, acceptability, and feasibility for this population limits the ability to effectively test and implement these interventions. There is a fundamental need to address this pre- implementation gap in knowledge so that later stages of intervention testing can advance the goal of reducing retraumatization during hospitalization for patients with serious illness and PTSS.
The long-term goal for this Ruth L. Kirschstein Predoctoral Individual National Research Service Award (NRSA) is to support research and training that allows the applicant to become an independent investigator who advances the science of psychosocial care delivery for patients with serious illness. To achieve this goal, the overall objective of the research proposal is to conduct a convergent mixed methods study that will address existing pre-implementation knowledge gaps regarding the context, acceptability, and feasibility of a palliative care social worker-led (PCSW) trauma-informed intervention, the Stepwise Psychosocial Palliative Care Model (SPPC). The study aims are to: 1) identify key contextual factors of retraumatization in the hospital among patients with serious illness, and 2) evaluate stakeholder perceptions of the acceptability and feasibility of the SPPC intervention.

The Training Plan includes four key goals: 1) expand theoretical and conceptual knowledge of trauma across the lifespan and the relationship between serious illness and PTSS; 2) strengthen training in quantitative, qualitative, and mixed methods design, data collection, and analysis; 3) expand implementation science knowledge and skills for intervention adaptation, testing, and implementation; and 4) increase writing, publishing, and dissemination skills in preparation for future stages of career research. This proposed study is aligned with the National Institute on Aging’s (NIA) Strategic Research Goal F: to elucidate psychological and social determinants of health related to processes and outcomes of aging with serious illness and will directly inform a future K23 application that proposes implementation mapping and a pilot feasibility study of the SPPC intervention among patients hospitalized with serious illness.

Grant Number: 1F31AG092099-01A1
NIH Institute/Center: NIH

Principal Investigator: Chelsea Brown

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