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A Magnetic Resonance Imaging Based Computational Analysis of Plaque Morphology and Hemodynamics in Patients with High Grade Asymptomatic Carotid Artery Stenosis

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2025 ⚠️
NIHUS FederalResearch GrantFY2025AccountingAnatomic SitesAnatomic structuresAnatomyAngiogramAngiographyApoplexyBiomechanicsBrain Vascular AccidentBrain Vascular DisordersCalibrationCarotid ArteriesCarotid Artery NarrowingCarotid Artery PlaquesCarotid Artery StenosisCarotid EndarterectomyCarotid StenosisCephalicCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeCerebrumCessation of lifeClinicalCompensationComputer AnalysisCranialDataDeathDiagnosisDiagnostic ImagingICA stenosisInternal Carotid Artery StenosisInterventionIntracranial Vascular DiseasesIntracranial Vascular DisordersIschemic StrokeLesionLiquid substanceLong-term disabilityMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModelingMorphologyNMR ImagingNMR TomographyNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresPathological ConstrictionPatient SelectionPatient imagingPatientsPerfusionPlaque InstabilityPostoperativePostoperative PeriodProtocolProtocols documentationQualifyingSeveritiesStenosisStressStrokeSurgicalSurgical InterventionsSurgical ProcedureTestingUnited StatesWorkZeugmatographyangiographic imagingarterial spin labelingarterial spin taggingbiomarker identificationbiomechanicalblood flow in brainbrain attackbrain blood circulationbrain blood flowbrain vascular diseasebrain vascular dysfunctioncarotid plaquecerebralcerebral blood flowcerebral circulationcerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebrocirculationcerebrovascular accidentcerebrovascular blood flowcerebrovascular dysfunctioncohortcomputational analysescomputational analysiscomputer analysesdetermine efficacyefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyfluidhemodynamicshigh riskidentification of biomarkersidentification of new biomarkersimaging in patientsimaging on patientsindexingintracranial vascular dysfunctionliquidmarker identificationpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypesplaque vulnerabilitypressurerepairrepairedrevascularizationrisk for strokerisk of strokeshear stressstroke patientstroke riskstrokedstrokessurgeryultrasoundunstable plaque

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PROJECT SUMMARY/ABSTRACT
Internal carotid artery (ICA) stenosis is a leading cause of stroke, long-term disability, and death.
Current assessment of ICA stenosis is based on estimation of % stenosis via duplex ultrasound (DUS)
or cross-sectional angiography. Landmark studies suggested that asymptomatic patients with stenotic
lesions >60% should…

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