grant
A Learning Health System Approach to Improve the Effectiveness of Blood Transfusions during Septic Shock
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AcuteAcute Lung InjuryAcute Pulmonary InjuryAdmissionAdmission activityAdoptionAdvisory CommitteesAnemiaAutologousBenchmarkingBest Practice AnalysisBloodBlood Reticuloendothelial SystemBlood TransfusionBlood erythrocyteBostonCaringCharacteristicsChronic DiseaseChronic IllnessClinicalClinical DataClinical TrialsCompetenceCritical CareCritical IllnessCritically IllDataData BasesData SetDatabasesDecision AidDevelopmentDevelopment PlansDropsDysfunctionEffectivenessEnvironmentErythrocyte TransfusionErythrocytesErythrocyticFailureFunctional disorderFutureGenerationsGoalsGuidelinesHctHealth systemHematocritHematocrit procedureHemoglobinHemoglobin concentration resultHeterogeneityHospital AdmissionHospitalizationHospitalsHybridsImmune responseIndividualInfectionInflammationIntensive Care UnitsInterventionInvestigatorsKnowledgeLeadershipLearningLinear ModelsMarrow erythrocyteMedicalMedical centerMentorsMethodologyMethodsModelingMorbidityMorbidity - disease rateNHLBINational Heart, Lung, and Blood InstituteOrganOutcomePacked Erythrocyte VolumePacked Red-Cell VolumePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPhysiopathologyPositionPositioning AttributePractice Pattern VariationsPreparationRandomized, Controlled TrialsRecommendationRed Blood Cell TransfusionRed Blood CellsRed CellResearchResearch PersonnelResearch PriorityResearch ResourcesResearchersResistanceResourcesRiskRisk ReductionSepsisSeptic ShockStandardizationState HospitalsTask ForcesTechniquesTestingTrainingTransfusionTranslatingUnited StatesUniversitiesVariantVariationWorkadvisory teamassess effectivenessbenchmarkblood corpusclescareer developmentchronic disorderclinical databaseclinical implementationclinical practiceclinically actionablecomparative effectivenessdata basedetermine effectivenessdevelopmentaleconometricseffectiveness assessmenteffectiveness clinical trialeffectiveness evaluationeffectiveness studyeffectiveness/implementation hybridevaluate effectivenessexamine effectivenessexperiencehemoglobin levelhost responseimmune system responseimmunoresponseimprovedindividuals with sepsismedical collegemedical schoolsmortalitynoveloutcome predictionpathophysiologypatient oriented outcomespatients with sepsispeople with sepsispreparationsrandomized control trialrandomized, clinical trialsreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresistantrisk-reducingschool of medicinesepsis groupssepsis patientssepsis populationsepsis subjectsseptic groupseptic individualsseptic patientsseptic peopleseptic populationseptic subjectskillssubjects with sepsistransfusion medicinetreatment effect
Description preview
PROJECT SUMMARY/ABSTRACT
Septic shock is a common, often fatal, dysregulated host response to infection that results in acute circulatory
failure. Almost all patients with septic shock either have anemia (i.e., low blood counts) on presentation or
develop anemia during hospitalization and anemia in septic shock is strongly associated with…
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