grant
A Genetics Approach to Candida albicans Gastrointestinal Colonization Resistance
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 20 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY202621+ years old5-Aminosalicylic AcidAblationAcidsAcute leukemiaAdultAdult HumanAlimentary CanalAnaerobiosisAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsApproaches to preventionAsacolAutoregulationBacteriaBlood CirculationBloodstreamButyratesC albicansC. albicansC.albicansCTXCYCLO-cellCancer TreatmentCancersCandidaCandida albicansCandidiasisCandidosisCarloxanCategoriesCausalityCell RespirationCellular Immune FunctionCellular Metabolic ProcessCellular RespirationCiclofosfamidaCiclofosfamideCicloxalClafenClapheneClassificationColonCycloblastinCycloblastineCyclophosphamCyclophosphamideCyclophosphamidumCyclophosphanCyclophosphaneCyclophosphanumCyclostinCyclostineCytophosphanCytophosphaneCytoxanD glucitolDataDefense MechanismsDevelopmentDevelopment and ResearchDietDigestive TractDiseaseDisorderDoseDrug usageDrugsEndoxanEndoxanaEnduxanEpithelial CellsEpitheliumEtiologyFecesFosfaseronFundingFungal Drug ResistanceFungus drug resistantFutureGI TractGI colonizationGI microbiotaGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGeneralized GrowthGenetics-MutagenesisGenoxalGenuxalGerm-FreeGlucitolGnotobioticGnotobioticsGoalsGrowthGut EpitheliumHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHomeostasisHyperoxiaHypoxiaHypoxicIditol DehydrogenaseImmune systemImpairmentIndividualInfectionInflammatory Bowel DiseasesInflammatory Bowel DisorderIntermediary MetabolismIntestinalIntestinesL iditol dehydrogenaseL-Iditol 2-DehydrogenaseLedoxinaLiverMalignant Hematologic NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMedicationMentorshipMesalamineMesalazineMetabolic ProcessesMetabolismMethodsMiceMice MammalsMiscellaneous AntibioticMitochondriaMitoxanModelingMoniliaMoniliasisMurineMusMutagenesisMutagenesis Molecular BiologyNeosarO elementO2 elementOutcomeOxygenOxygen ConsumptionOxygen DeficiencyPentasaPersonsPharmaceutical PreparationsPhysiological HomeostasisPolyol DehydrogenasePopulationPositionPositioning AttributePost-vaccination infectionPrevention approachProcytoxProphylactic treatmentProphylaxisR & DR&DResearchResearch ResourcesResourcesRoleRowasaRunningSendoxanSorbitolSorbitol DehydrogenaseSpleenSpleen Reticuloendothelial SystemSupplementationSyklofosfamidSystematicsTestingTherapeuticTherapeutic FungicidesTherapeutic InterventionTissue GrowthTrainingTransplant RecipientsVirulenceWorld Health OrganizationYeastsZytoxanadulthoodaerobic metabolismaerobic respirationalimentary tractanti-cancer therapyanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantbacterial disease treatmentbacterial infectious disease treatmentbowelbreakthrough infectioncancer therapycancer-directed therapycandidaemiacandidemiacausationcell metabolismcellular metabaolismchemotherapyclinical relevanceclinically relevantcolonization resistancecomputerized data processingdata processingdevelopmentaldietsdigestive canaldisease causationdrug usedrug/agententeric microbial communityenteric microbiotafecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal transplantfecal transplantationfungusfungus drug resistancegastrointestinalgastrointestinal epitheliumgastrointestinal microbial floragastrointestinal tract colonizationgenetic approachgenetic strategyglobal healthgut colonizationgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahepatic body systemhepatic organ systemhigh riskhyperoxygenationimmune functionimplantationimproved outcomein vitro Modelinflammatory disease of the intestineinflammatory disorder of the intestineinnovateinnovationinnovativeinsightintervention therapyintestinal autoinflammationintestinal colonizationintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloraleukemia treatmentleukemic therapym-Aminosalicylic Acidmalignancymeta-Aminosalicylic Acidmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmicrobialmicrobial consortiamicrobial floramicrobiotamicrobiota compositionmicrofloramitochondrialmortalitymultispecies consortiamutantneoplasm/cancernew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetontogenyopportunistic pathogenoxidative metabolismpathogenpreventpreventingprogramsprophylacticpsychological defense mechanismresearch and developmentresistance to anti-fungalresistant to anti-fungalrestorationsocial rolestoolsugartransplant patientyeast infection
Description preview
PROJECT SUMMARY/ABSTRACT
The World Health Organization classified Candida albicans as a critical pathogen warranting increased
research and development needs. C. albicans is the most common etiology of invasive candidiasis, which
occurs when C. albicans enters the blood stream (candidemia) and disseminates throughout the body (i.e. the
liver and…
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