grant
A Functional Genomics Approach to Uncover the Mechanisms of Neutrophil Galvanotaxis.
Organization UNIVERSITY OF COLORADOLocation Boulder, UNITED STATESPosted 16 Sept 2022Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025ActinsActomyosinAcuteAssayAwardBehaviorBioassayBiochemicalBiological AssayBiological FunctionBiological ProcessBiologyBlood NeutrophilBlood Polymorphonuclear NeutrophilCRISPR approachCRISPR based approachCRISPR interferenceCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR-dCas9-mediated repressionCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCancersCandidate Disease GeneCandidate GeneCas nuclease technologyCategoriesCell BodyCell Communication and SignalingCell DeathCell LocomotionCell MigrationCell MovementCell SignalingCell-Extracellular MatrixCellsCellular MatrixCellular MigrationCellular MotilityChemicalsChemotaxisClinicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats interferenceClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsCollectionCommunicationComplexComputer ModelsComputer SimulationComputer based SimulationComputerized ModelsCuesCytoplasmic GranulesCytoskeletal SystemCytoskeletonDNA Molecular BiologyDataDevelopmentDevice DesignsDevicesECMEducational process of instructingEngineeringEnvironmentExhibitsExtracellular MatrixExtracellular SpaceFluorescence Light MicroscopyFluorescence MicroscopyGene TargetingGenesGenomic DNAGenomic approachGoalsGrantHL-60HL-60 CellsHL60HL60 CellsHumanHuman Cell LineImmuneImmunesInfectionInflammationInjuryInnate Immune SystemIntercellular SpaceIntracellular Communication and SignalingLaboratoriesLeadershipMalignant CellMalignant NeoplasmsMalignant TumorMarrow NeutrophilMechanicsMembraneMentorsModern ManMolecularMolecular BiologyMotilityNeutrophilic GranulocyteNeutrophilic LeukocytePatternPhagocytosisPhasePhenotypePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPostdocPostdoctoral FellowProcessProliferatingPropertyProteinsProtocolProtocols documentationReceptor ProteinReporterResearchResearch AssociateRoleShapesSignal TransductionSignal Transduction SystemsSignalingSpeedTeachingTechniquesTechnologyTestingTrainingWorkWound RepairWritingassay developmentbioelectricbioelectricitybiological signal transductioncancer cellcareercell motilityclinical applicabilityclinical applicationcomputational modelingcomputational modelscomputational simulationcomputer based modelscomputerized modelingcomputerized simulationcytotoxicdevelopmentalelectric fieldelectrical potentialexperimentexperimental researchexperimental studyexperimentsextracellularfirst responderfunctional genomicsgDNAgenome scalegenome wide screengenome-widegenomewidegenomic effortgenomic strategygranuleimprovedinjuriesinsightintracellular skeletonknock-downknockdownmalignancymechanicmechanicalmembrane structuremigrationnecrocytosisneoplasm/cancerneutrophilpathogenpost-docpost-doctoralpost-doctoral traineepreventpreventingprogramsreceptorreceptor bindingreceptor boundrepressing CRISPR-dCas9 systemresearch associatesresponsesocial rolesuccesssuicidalsuicidalitytoolvoltagewound healingwound recoverywound resolution
Description preview
Project Summary/Abstract
During acute inflammation our immune cells orchestrate a complex, but coordinated mitigation response.
Immune cells are especially good at navigating the complex extracellular environment through dynamic
modulation of their actomyosin cytoskeletons, enabling a rapid and effective response throughout the body. The
ability…
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