grant
A CRISPR-based sensitive liquid biopsy for endometrial cancer using tumor-derived hallmarks (CRISPR SLEUTH)
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 14 May 2026Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026AddressAdoptedAgeAlgorithmsAssayAutomationBMIBMI percentileBMI z-scoreBenignBioassayBioinformaticsBiological AssayBiological MarkersBiologyBiomedical EngineeringBiometricsBiometryBiosensing TechnicsBiosensing TechniquesBiostatisticsBiotechBiotechnologyBody mass indexCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer BiologyCancer DiagnosticsCancersCarcinomaCas nuclease technologyCell Communication and SignalingCell SignalingCessation of lifeClinicalClinical OncologyClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollectionCytolysisDeathDeath RateDetectable Residual DiseaseDetectionDiagnosisDiagnosticDiseaseDisorderDisparitiesDisparityEarly DiagnosisEndometrialEndometrial CancerEndometrial CarcinomaEndometrioid AdenocarcinomaEndometrioid CarcinomaEndometrioid Carcinoma of the Female Reproductive SystemEndometrioid adenomas and carcinomasEndometrium CancerEndometrium CarcinomaEpithelial cancerEvaluationEvolutionExhibitsFemale Reproductive Endometrioid CarcinomaGTExGenotype-Tissue Expression ProjectGoalsGynecologicGynecologic OncologyHeatingHeterogeneityHistologyHysteroscopyIncidenceIntracellular Communication and SignalingLaboratoriesLesionLysisMalignantMalignant - descriptorMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant NeoplasmsMalignant TumorMessenger RNAMinimal Residual DiseaseModalityModelingMolecularMolecular FingerprintingMolecular ProfilingMonitorNatureNon-Polyadenylated RNANucleic AcidsOrganoidsPatientsPropertyProteinsQuetelet indexRNARNA Gene ProductsRNA replicationReactionRecurrenceRecurrentRelapseReporterResearchResearch ResourcesResearch SpecimenResidual NeoplasmResidual TumorsResourcesRibonucleic AcidRisk FactorsSamplingSerousSignal TransductionSignal Transduction SystemsSignalingSingle Base PolymorphismSingle Nucleotide PolymorphismSourceSpecimenSystemTCGATechnologyTestingThe Cancer Genome AtlasTimeTranslationsTransvaginal UltrasoundTumor-DerivedUrineUterine EndoscopyUteroscopyUterusVariantVariationWomanagesbio-engineeredbio-engineersbio-markersbiobankbioengineeringbiologic markerbiological engineeringbiological signal transductionbiomarkerbiomarker identificationbiorepositorybiosensingcancer sub-typescancer subtypescandidate biomarkercandidate markerclinical relevanceclinically relevantcommercializationcost effectivedetection limitearly detectionendometrioid cancerendometroid cancerendometroid carcinomaepithelial carcinomaexpectationexperienceextracellular vesiclesidentification of biomarkersidentification of new biomarkersinnovateinnovationinnovativeinstrumentliquid biopsymRNAmalignancymarker identificationminimally invasivemolecular profilemolecular signaturemortality ratemulti-modalitymultimodalitynanonano particlenano-sized particlenanoparticlenanosized particleneoplasm/cancernew diagnosticsnext generationnext generation diagnosticsnovelnovel diagnosticsnucleaseoperationoperationsoptimal therapiesoptimal treatmentsoverexpressoverexpressionplasmonicspre-clinical studypreclinical studyprognosticprospectivepublic data basepublic databasepublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databaserepurposingresidual diseasesingle nucleotide varianttranslationtrendtumorurinarywomb
Description preview
Challenges. Endometrial cancer (EC) exhibits increasing incidence and mortality rates, contrasting with trends
observed in most other cancers. Notably, uterine serous carcinoma (USC) is a distinct subtype typically
presenting at advanced stages with an associated poor 5-year survival (<20% for stages III and IV) and high
recurrence rates (up to…
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