grant
A cord-blood specific subset of human gamma-delta T cells with distinct functional features
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 3 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years old5 year old5 years of ageAdultAdult HumanAgeAssayBacteriaBaltimoreBioassayBiological AssayBirthCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD56CITE sequencingCITE-seqCITEseqCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular Indexing of Transcriptomes and Epitopes by SequencingCellular PhysiologyCellular ProcessCellular biologyChildChild YouthChildren (0-21)Chronologic Fetal MaturityClinicalConsensusCord BloodDataData AnalysesData AnalysisData SetExposure toExpression SignatureFetal AgeFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsFutureGamma-delta T cellsGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionGestational AgeGoalsHeterogeneityHumanHuman GeneticsImmuneImmune systemImmunesImmunityImmunochemical ImmunologicImmunocompetenceImmunologicImmunologic CompetenceImmunologicalImmunological CompetenceImmunologicallyImmunologicsImmunologistInfantInfectionKnowledgeLearningLifeLymphatic cellLymphocyteLymphocyticMapsMarylandMeasuresMedicineMiceMice MammalsModern ManMolecularMurineMusNCAMNCAM1NCAM1 geneNeonatalOutcomePD 1PD-1PD1ParturitionPhenotypePopulationPredispositionPremature InfantProductionProliferatingPropertyProtozoaProtozoalRNA ExpressionResearch SpecimenRoleSamplingSpecimenStem Cell likeSubcellular ProcessSusceptibilityT cell responseT-CellsT-LymphocyteT4 CellsT4 LymphocytesTechniquesTranscriptionUmbilical Cord BloodVirusadulthoodage 5age 5 yearsagesanti-microbialantimicrobialcell biologycellular indexing of transcriptomes and epitopes by single cell sequencingcholesterol biosynthesiscytokinecytotoxicdata interpretationexperimentexperimental researchexperimental studyexperimentsexposed in uterofetal cord bloodfetal exposurefightingfive year oldfive years of ageflow cytophotometrygene expression patterngene expression signaturehigh riskimprovedin utero exposureinfancyinfant infectioninfantileinfants born prematureinfants born prematurelyinfected infantintra-uterine environmental exposureintrauterine environmental exposurekidslymph cellmicrobialmicroorganismmortalitymouse modelmultidisciplinarymurine modelneonatal humanneonateoverexpressoverexpressionpathogenpremature babypremature infant humanprenatal exposureprenatally exposedpreterm babypreterm infantpreterm infant humanprogenitor capacityprogenitor cell likeprogenitor-likeprogenitor-like cellprogrammed cell death 1programmed cell death protein 1programmed death 1programsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2social rolestem cell characteristicsstem-likestem-like cellstemnesssystemic lupus erythematosus susceptibility 2thymus derived lymphocytetranscriptional profiletranscriptional signatureyoungsterγδ T cellsγδT cells
Description preview
Infants are especially susceptible to intracellular pathogens because their immune system is not fully equipped
to fight against these microorganisms. As a result, infant infections are a leading cause of mortality, with >1.5
million children dying of infections before 5 years of age in 2022 alone. The current consensus is that
before birth,…
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