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A Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents

Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Mar 2023Deadline 31 May 2025 ⚠️
NIHUS FederalResearch GrantFY202512-20 years oldAccidentsActive Follow-upAddressAdolescenceAdolescentAdolescent YouthAfter CareAfter-TreatmentAftercareBehaviorBehavioralBiologicalBlindedChronicCircadian RhythmsCognitiveDataDevelopmentDiagnosticDietDoseEmotional DepressionExerciseExperimental TherapiesFailureFundingFutureHealthImpairmentIndividualInterventionInvestigational TherapiesInvestigational TreatmentsLightMajor Depressive DisorderMeasurementMeasuresMediatingMelatoninMental DepressionMoodsNational Institutes of HealthNyctohemeral RhythmOutcomePatientsPhasePhotoradiationPublic HealthROC AnalysesROC CurveRandomized, Controlled TrialsRecurrenceRecurrentResearchSchoolsSeveritiesSleepStressSubgroupTestingTherapeutic EffectTimeTreatment outcomeTwenty-Four Hour RhythmUnited States National Institutes of HealthWorkYouthYouth 10-21active controlactive followupadolescence (12-20)adolescent depressionadolescents with depressionanti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsbehavioral sleep health interventionbehavioral sleep health programbehavioral sleep interventionbehavioral sleep strategiesbehavioral sleep therapybehavioral sleep treatmentbiologicchild depressionchildhood depressionchildhood onset depressionchildren's depression rating scalecircadiancircadian biologycircadian processcircadian rhythmicityclinical depressionclinical significanceclinically significantconfirmatory efficacy trialconfirmatory trialdaily biorhythmdepressed adolescentsdepressiondepression in adolescencedepression symptomdepressivedepressive symptomsdesigndesigningdevelopmentaldietsefficacy studyevidence baseexperienceexperimental therapeutic agentsexperimental therapeuticsfollow upfollow-upfollowed upfollowupimprovedjuvenilejuvenile humanmajor depressionmajor depression disordernovelpediatric depressionpost treatmentprecision medicineprecision-based medicinepreferencepsychoeducationpsychosocialrandomized control trialreceiver operating characteristic analysesreceiver operating characteristic curveresponsesocial stigmastigmasuicidalsuicidalitytherapy optimizationtreatment optimizationyouth ageyouth depression

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Project Summary
Major Depressive Disorder (MDD) in adolescence is associated with significant psychosocial impairment,
health problems, school failure, and suicidality. Many youth remain substantially symptomatic despite receiving
current first-line treatments, underscoring the need for novel, modifiable targets to improve depression
treatment…

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