grant
A comprehensive platform for low-cost screening and image-guided photodynamic therapy (PDT) of pre-malignant and malignant oral lesions in low resource settings
Organization UNIVERSITY OF MASSACHUSETTS BOSTONLocation BOSTON, UNITED STATESPosted 15 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3D5-ALA5-Amino-4-oxopentanoic Acid5-Aminolevulinic Acid5-amino-4-oxo-pentanoic acidAI AugmentedAI assistedAI basedAI based platformAI drivenAI enhancedAI integratedAI platformAI poweredAI systemAddressAdhesivesAdoptionAfter CareAfter-TreatmentAftercareAgreementAmino-Levulinic AcidArtificial IntelligenceArtificial Intelligence enhancedArtificial Intelligence platformAstronomyAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIAwardBuccaBuccal CavityBuccal Cavity Head and NeckBuccal MucosaCancer Causing AgentsCancersCapitalCarcinogensCarcinoma in SituCavitas OrisCessation of lifeCheekCheek structureChewingClassificationClinicalCollaborationsComputer ReasoningConvNetCountryCricetinaeDataDeathDelta-Aminolevulinic AcidDetectionDevelopmentDevicesDiagnosisDiseaseDisease ProgressionDisorderEconomic IncomeEconomical IncomeEligibilityEligibility DeterminationEngineeringFDA approvedFamily suidaeFluorescenceFutureGermanyGoalsHamstersHamsters MammalsHeterograftHeterologous TransplantationHigh grade dysplasiaHistologicHistologicallyHistopathologyImageImaging DeviceImaging InstrumentImaging ToolIn VitroIncidenceIncomeIndiaIndividualIndustryInfrastructureIntraepithelial CarcinomaLesionLettersLightLow incomeLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMachine IntelligenceMalignantMalignant - descriptorMalignant NeoplasmsMalignant Oral Cavity NeoplasmMalignant Oral Cavity TumorMalignant Oral NeoplasmMalignant TumorMasticationMedicalMiceMice MammalsModalityModelingMonitorMouthMouth CancerMouth MucosaMucosaMucosal TissueMucous MembraneMurineMusOncogensOncologistOpticsOralOral CancerOral MucosaOral StageOral cavityOral mucous membrane structureOutcomePUVAPUVA PhotochemotherapyParticipantPathologyPatientsPenetrationPerformancePhotobleachingPhotochemistryPhotochemotherapyPhotodynamic TherapyPhotoradiationPhotosensitizationPhotosensitizersPhotosensitizing AgentsPigsPreinvasive CarcinomaPropertyProtocol ScreeningPublic HealthRadiation therapyRadiotherapeuticsRadiotherapyResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingSafetyScientistScreening for Oral CancerScreening for cancerSensitivity and SpecificitySiteSuidaeSurgeonSurgical OncologySwineSystemSystematicsTechnologyTestingTherapeutic AgentsTimeTopical Drug AdministrationTopical applicationTrainingTreatment EfficacyTumor BurdenTumor LoadWorkXenograftXenograft ModelXenograft procedureXenotransplantationapply topicallyartificial intelligence assistedartificial intelligence augmentedartificial intelligence basedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredcancer locationcancer sitecarcinogenicitychewedchewsclinical centerclinical implementationclinical validationcloud basedcohortconvolutional networkconvolutional neural netsconvolutional neural networkcostd-Amino-Levulinic Aciddeep learningdeep learning methoddeep learning strategydeliver topicallydesigndesigningdevelopmentaldosimetryearly cancer detectionenhanced with AIenhanced with Artificial Intelligenceergonomicsexperiencehandheld devicehandheld equipmenthealinghigh riskimage classification algorithmimage classification approachimage classification methodimage classification modelimage classification toolimage classifierimage guidanceimage guidedimage-based classifierimagingimaging systemin situ cancerinclusion criteriaincomesinnovateinnovationinnovativeintervention efficacyintraoral probelight weightlightweightmalignancymalignant mouth neoplasmmalignant mouth tumormeetingmeetingsmolecular imagingmolecule imagingmouth lesionneoplasm/cancerneoplasm/cancer photoradiation therapyoncogenic agentoncologic surgeryopticaloral cancer early detectionoral cavity canceroral lesionoral mucosaeoral mucosaloral precanceroral premalignancypatient screeningphotosensitizerpoint of careporcineportabilitypost treatmentpre-clinicalpre-clinical studyprecancerprecancerouspreclinicalpreclinical studypremalignantradiation treatmentresponserural arearural localityrural locationrural placerural regionrural settingscreeningscreening cancer patientsscreeningsspace sciencesubcutaneoussubdermalsuccesssuidsystemic toxicitytherapeutic efficacytherapeutic evaluationtherapeutic testingtherapy efficacythree dimensionaltopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttreat topicallytreatment with radiationtumorvalidation studiesxeno-transplantxeno-transplantationxenograft transplant modelxenotransplant model
Description preview
Motivated by the bleak situation of oral cancer in India and encouraged by our successes in the UH2/UH3
mechanism for diagnosing and treating pre- and early cancers, a new integrated “Screen, Image and Treat
Optical System” (SITOS) is proposed in the current application which combines the expertise of 3 US sites in
collaboration with 2 clinical…
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