grant
4/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 25 Sept 2017Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years oldAccelerationActive Follow-upAcuteAddressAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican ancestryAfrican descentAfro AmericanAfroamericanAlabamaAlbuminsAllograftingAmericanAntibodiesApolipoproteinsArkansasBacterial InfectionsBiopsyBloodBlood Reticuloendothelial SystemBlood SerumChildChild YouthChildren (0-21)ClinicalClinical DataConsentCost SavingsCounselingCreatinineDNADataDeoxyribonucleic AcidDisparitiesDisparityDonor personEducationEducational aspectsEnrollmentEnsureEnvironmental FactorEnvironmental Risk FactorEuropeanEvaluationFaceFailureFoundationsGene variantGenesGeneticGenetic predisposing factorGenotypeGeographyGraft SurvivalHL-A AntigensHLA AntigensHealth Care CostsHealth CostsHuman Leukocyte AntigensImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInformed ConsentKidneyKidney DiseasesKidney FailureKidney GraftingKidney InsufficiencyKidney TransplantationKidney TransplantsKidney Urinary SystemLeadLesionLeukocyte AntigensLiving DonorsLong-term Follow-upMeasuresMedicalMedical centerMississippiNational Institutes of HealthNephropathyOrganOutcomeOutcome AssessmentOutcome StudyParticipantPatternPb elementPersonsPhasePhenotypePoliciesPrevalenceProcessProteinuriaQOLQuality of lifeRecurrent diseaseRegistriesRelapsed DiseaseRenal DiseaseRenal FailureRenal GraftingRenal InsufficiencyRenal TransplantationRenal TransplantsRenal functionReportingResearchRiskRisk-associated variantRoleSafetyScienceSerumSiteSlideSouth CarolinaTimeTransplant RecipientsTransplantationUNOSUnited Network for Organ SharingUnited States National Institutes of HealthUniversitiesUrineVariantVariationViral DiseasesVirus Diseasesactive followupallelic variantbacteria infectionbacterial diseaseclinical centerco-morbidco-morbiditycohortcomorbiditydamage to kidneydeceased donordeceased organ donorsdepositorydifferences due to racedifferences in racediffers by racediffers in racedigital pathologyenrollenvironmental riskethnic differenceethnicity differencefacesfacialfollow upfollow-upfollowed upfollowupgene interactiongenetic risk factorgenetic variantgenomic variantgraft failureheavy metal Pbheavy metal leadhigh riskimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinherited factorkidney allograftkidney biopsykidney damagekidney disorderkidney functionkidney txkidslive kidney donorliving kidney donorlong-term followupnovelorgan allocationphase 2 studyphase II studypost-transplantpost-transplantationposthumous donorsposthumous organ donorposttransplantposttransplantationprimary outcomeprogramsprospectiverace based differencesrace differencesrace related differencesracial differenceracially differentrecruitrenalrenal allograftrenal biopsyrenal damagerenal disorderrepositoryrisk allelerisk generisk genotyperisk locirisk locusrisk variantsecondary outcomesocial roletransplanttransplant donortransplant patientviral infectionvirus infectionvirus-induced diseaseyoungster
Description preview
Abstract
Kidneys from deceased African American donors have reduced allograft survival compared to kidneys from
donors from European Americans. Likewise, kidneys from deceased donors with 2 apolipoprotein L1 gene
(APOL1) renal-risk variants, defined as APOL1 high-risk genotypes, have shorter allograft survival. Importantly,
many kidneys…
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