grant
3D Chromatin architectural dynamics at ultra-high resolution
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAccelerationAcuteAllelesAllelomorphsAppearanceApplications GrantsArchitectureAttentionB-globinBasal Transcription FactorBasal transcription factor genesC3 dC3dCell BodyCell CycleCell Cycle ProgressionCell Division CycleCell LineCellLineCellsChromatinChromatin AssemblyChromatin LoopChromatin Loop DomainsChromatin ModelingChromosomesClosure by LigationComplementComplement 3dComplement C3dComplement ProteinsDNA LoopDataDelta transcription factorDiseaseDisorderDistalE1A Binding Protein p300ENX-1EP300EP300 geneESETEZH1EZH2EZH2 geneElementsEngineering / ArchitectureEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitEnhancersErythroblastsEuchromatinF-ACT1 proteinFirst Gap PhaseG1 PhaseG1 periodG1/S TransitionGap Phase 1Gene Action RegulationGene ActivationGene Down-RegulationGene ExpressionGene Expression RegulationGene InactivationGene RegulationGene Regulation ProcessGene SilencingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenomeGoalsGrant ProposalsHeterochromatinHeterogeneityHi-CImageInterphaseKAT3BKG1TKIAA0067KMT6KMT6ALaboratoriesLengthLigationM PhaseMachine LearningMapsMediatingMethodsMinorityMitosisMitosis StageMitoticModelingNF-D nuclear factorNF-E1 proteinNMP-1 proteinNormoblastsNucleated ErythrocytesNucleated red blood cellNucleated red cellPatternPhase TransitionPolymersPopulationPro-MetaphasePrometaphaseProteinsRNA ExpressionRegulatory ElementRepressionResolutionRoleSETDB1SETDB1 geneSeriesStrains Cell LinesStructureSurvey InstrumentSurveysSystemTechnologyTestingTimeTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription RepressionTranscription factor genesUCRBP proteinValidationVariantVariationWorkYY1YY1 Transcription FactorYY1 proteinYin-Yang-1 proteinbeta Globinbiological systemscohesincomplementationcondensincultured cell linedelta factorepigenome profilingepigenomic profilingepigenomicsexperimentexperimental researchexperimental studyexperimentsgene repressiongenome scalegenome-widegenomewidehigh definitionhigh-resolutionhistone acetyltransferase p300imaginginsightinterestmachine based learningmachine learning based modelmachine learning modelmammalian genomenuclear matrix protein 1nucleated RBCsp300polymerpolymericresolutionssocial rolesuper high resolutionsuperresolutionthree dimensionaltooltranscription factortranscriptional silencingultra high resolutionultra resolutionultrafine resolutionvalidationsyin-yang-1β-globin
Description preview
Project Summary/Abstract
This proposal will investigate the dynamic 3D folding of the genome at ultra-high resolution across length and
time scales as it relates to gene activity. Studies in Aim 1 will investigate how newly discovered
“microcompartments” between active cis-regulatory elements (CREs) form as cells exit mitosis and enter G1
phase.…
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