grant
3/14 ApoL1 Long-Term Kidney Transplantation Outcomes Network (Apollo) Clinical Center
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 25 Sept 2017Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AIDS NephropathyAIDS-Associated NephropathyAIDS-Related NephropathyAPOL-IAPOL1APOL1 geneAccelerationActive Follow-upAcuteAddressAfrica South of the SaharaAfrican AmericanAfrican ancestryAfrican descentAfro AmericanAfroamericanAlbuminsAllelesAllelomorphsAllograftingAmericanAntibodiesApolipoproteinsBacterial InfectionsBiologicalBiopsyBloodBlood Reticuloendothelial SystemBlood SerumCC3ClinicalClinical DataConsentCost SavingsCounselingCreatinineDNADataDeoxyribonucleic AcidDisparitiesDisparityESKDESRDEducationEducational aspectsEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEnrollmentEnsureEuropeanEvaluationFSGSFaceFailureFocal and Segmental GlomerulosclerosisFocal segmental glomerular sclerosisFutureGene variantGenesGeneticGenotypeGeographyGraft SurvivalHIV-Associated NephropathyHIV-Related NephropathyHL-A AntigensHLA AntigensHTATIP2 geneHealth Care CostsHealth CostsHuman Immunodeficiency Virus-Associated NephropathyHuman Leukocyte AntigensHypertensionImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInvestigatorsKidneyKidney DiseasesKidney FailureKidney GraftingKidney InsufficiencyKidney TransplantationKidney TransplantsKidney Urinary SystemLesionLeukocyte AntigensLiving DonorsLong-term Follow-upMeasuresMedicalNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthNephropathyOrganOutcomeOutcome AssessmentOutcome StudyParticipantPatientsPatternPersonsPhasePhenotypePoliciesPrevalenceProteinuriaQOLQuality of lifeRecurrent diseaseRegistriesRelapsed DiseaseRenal DiseaseRenal FailureRenal GraftingRenal InsufficiencyRenal TransplantationRenal TransplantsRenal functionReportingResearchResearch DesignResearch PersonnelResearch ResourcesResearch SpecimenResearchersResourcesRiskRisk-associated variantRoleSafetySamplingSerumSiteSlideSpecimenStudy TypeSub-Saharan AfricaSubsaharan AfricaTIP30TimeTransplant RecipientsTransplantationUNOSUnited Network for Organ SharingUnited StatesUnited States National Institutes of HealthUniversitiesUrineVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderViral DiseasesVirus DiseasesVital Statusactive followupallelic variantbacteria infectionbacterial diseasebiologicclinical centerclinical practicecohortdeceased donordeceased organ donorsdepositorydifferences due to racedifferences in racediffers by racediffers in racedigital pathologyenrollethnic differenceethnicity differencefacesfacialfollow upfollow-upfollowed upfollowupfunctional outcomesgene interactiongenetic variantgenomic variantgraft failurehigh blood pressurehigh riskhyperpiesiahyperpiesishypertensive diseasehypertensive disorderimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedkidney allograftkidney biopsykidney disorderkidney functionkidney txlong-term followupnovelpost-transplantpost-transplantationposthumous donorsposthumous organ donorposttransplantposttransplantationprimary outcomeprogramsprospectiverace based differencesrace differencesrace related differencesracial differenceracially differentrate of changerecruitrenalrenal allograftrenal biopsyrenal disorderrepositoryrisk allelerisk generisk genotyperisk locirisk locusrisk variantsecondary outcomesocial rolestudy designtransplanttransplant patientviral infectionvirus infectionvirus-induced disease
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Project Summary
Genetic variants in APOL1 commonly found in people of Western Sub-Saharan Africa ancestry
are associated with kidney diseases such as Focal Segmental Glomerulosclerosis, Hypertension
Attributed-End Stage Kidney Disease, and HIV-Associated Nephropathy. The presence of 2
APOL1- renal risk variants (RRV) in deceased donors is…
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