grant
2/3 Sequencing and Trans-Diagnostic Phenotyping of Severe Mental Illness in Diverse Populations
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Sept 2022Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AfricaAmericasAsiaAssayBioassayBiological AssayBipolar 1Bipolar ICausalityClinicalCodeCoding SystemCollaborationsConsentContracting OpportunitiesContractsDNADataData SetDeoxyribonucleic AcidDepositDepositionDevelopmentDiagnosisDiagnosticDirect CostsDiseaseDisorderEast AsiaEastern AsiaEducational process of instructingEthicsEtiologyEuropeFar EastFundingGWA studyGWASGenesGeneticGenetic DiversityGenetic VariationGenomicsGenotypeHumanIndividualInvestigatorsJobsKnowledgeLearningMajor Depressive DisorderManiasManicManic StateMeasuresMental disordersMental health disordersMeta-AnalysisMethodsModern ManMoonNIMHNational Institute of Mental HealthOccupationsOutputPaperPatientsPhasePhenotypePoliciesPopulation HeterogeneityProcessProfessional PositionsPsychiatric DiseasePsychiatric DisorderPsychiatryPsychosesResearchResearch PersonnelResearchersResource SharingRisk-associated variantRoleSNP arraySNP chipSample SizeSamplingSchizoaffective DisordersSchizophreniaSchizophrenic DisordersScienceSeveritiesSiteTOPMedTeachingTechnologyTherapeuticTrainingTrans-Omics for Precision MedicineTravelVariantVariationWorkcausationchronic mental illnessclinical depressioncostdata archivedata archivesdata sharingdeath riskdementia praecoxdevelopmentaldiscover genesdisease causationdiverse populationsethicalexomeexome sequencingexome-seqgene discoverygenetic architecturegenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variationheterogeneous populationindelinsertion/deletioninsertion/deletion mutationlow income countrymajor depressionmajor depression disordermental illnessmortality risknew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypersistent mental illnesspopulation diversityprogramspsychiatric genomicspsychiatric illnesspsychological disorderresistance to therapyresistant to therapyrisk allelerisk generisk genotyperisk locirisk locusrisk variantschizophrenicsecondary analysisserious mental disorderserious mental illnesssevere mental disordersevere mental illnesssevere psychiatric disordersingle nucleotide polymorphism arraysingle nucleotide polymorphism chipsocial roletherapeutic resistancetherapy resistanttreatment resistancewhole genome association analysiswhole genome association study
Description preview
Project Summary
In this new and unfunded study, we will capitalize on the lessons from the past 15 years of psychiatric
genomic. Based on these lessons, we propose an exceptionally novel and important set of aims to further
knowledge of the genetic architecture of mental illness. We propose to perform whole-exome sequencing and
SNP-array…
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