grant
WNT5a/ROR2-Mediated Hippo Pathway Activation in Prostate Cancer
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AgonistAndrogenic AgentsAndrogenic CompoundsAndrogensBasal Transcription FactorBasal transcription factor genesBeta Cadherin-Associated ProteinBeta-1 CateninBindingBiological MarkersCBDCACPT7CUL-2CYP17CYP17A1CYP17A1 geneCancer CauseCancer EtiologyCancersCarboplatinCarboplatinoCell Communication and SignalingCell SignalingCessation of lifeClinicalClinical TrialsComplexDNA DamageDNA InjuryDataDeathDefectDrugsFamilyFeedbackGNRHGNRH1GNRH1 geneGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenerationsGonadotropin Releasing Hormone 1GrowthIntracellular Communication and SignalingLNRHLigand BindingLinkLuteinizing Hormone-Releasing HormoneMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMediatingMediatorMedicationMerlinMoesin-Ezrin-Radixin-Like ProteinMolecularMolecular InteractionNF2NF2 Gene ProductNF2 geneNTRKR1Neuroendocrine Prostate CancerNeurofibromatosis 2 Gene ProductNeurofibromatosis 2 GenesNeurofibromatosis Type 2 ProteinNeurofibromin 2Neurotrophic Tyrosine Kinase Receptor-Related 1NuclearP450C17PARP InhibitorPARP-1 inhibitorPARPiPDX modelPRO2286Pathway interactionsPatient derived xenograftPatientsPharmaceutical PreparationsPhysiologicPhysiologicalPoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) polymerase 1 inhibitorPrognosisProstateProstate CAProstate CA therapyProstate CancerProstate Cancer therapyProstate GlandProstate malignancyProstatic GlandProteinsROR1ROR1 geneReceptor ProteinReceptor Tyrosine Kinase-Like Orphan Receptor 1ReportingResistanceS17AHSamplingSchwannomerlinSchwannominSchwannomin ProteinSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSolid NeoplasmSolid TumorTestingTherapeuticTherapeutic AndrogenTissue GrowthTranscription Factor Proto-OncogeneTranscription factor genesTumor PromotionWNT Signaling PathwayWNT signalingXtandiabirateroneandrogen ablation therapyandrogen blockade therapyandrogen deprivation therapyandrogen deprivation treatmentandrogen independent prostate cancerandrogen indifferent prostate cancerandrogen insensitive prostate cancerandrogen resistance in prostate cancerandrogen resistant prostate cancerantagonismantagonistbeta catbeta cateninbio-markersbiologic markerbiological signal transductionbiomarkerbiomarker identificationcartilage link proteincastration resistant CaPcastration resistant PCacastration resistant prostate cancerdeprivationdetermine efficacydrug/agenteffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenzalutamideevaluate efficacyexamine efficacyhormone refractory prostate canceridentification of biomarkersidentification of new biomarkersinhibitorlink proteinmalignancymarker identificationmenmimeticsneoplasm/cancernf 2 Genesnovelontogenypathwaypatient derived xenograft modelplanar cell polaritypredict responsivenesspredicting responseprostate cancer resistant to androgenprostate cancer treatmentreceptorresistance mechanismresistantresistant mechanismresponserestraintstandard of caretaxanetranscription factortumorβ-catenin
Description preview
Androgen deprivation remains the standard systemic treatment for prostate cancer (PCa) that has spread
beyond the prostate, but most patients progress to metastatic castration-resistant prostate cancer (mCRPC).
Many of these tumors will respond to abiraterone or to second generation AR antagonists, but resistance
inevitably develops. Some patients…
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