grant
Wisconsin longitudinal study: Initial lifetime's impact on Alzheimer's disease and related disorders (WLS-ILIAD)
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 15 Sept 2018Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AD and related dementiaAD biological markerAD biomarkerAD dementiaAD diagnosticAD pathologyAD related biomarkerAD related dementiaAD riskAD risk factorADRDActive Follow-upAddressAfrican AmericanAfro AmericanAfroamericanAgeAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's diagnosticAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease diagnosticAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related biomarkerAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's pathologyAlzheimer's related biomarkerAlzheimers DementiaAlzheimer’s biological markerAmentiaAmyloidAmyloid SubstanceAttentionBackBehavioralBiologic SciencesBiologicalBiological MarkersBiological SciencesBioscienceBirthBlackBlack raceBloodBlood PlasmaBlood Reticuloendothelial SystemBrain scanCensusesCerebrospinal FluidClinicClinicalCognitionCognitiveCollectionCommunitiesDataData SetDementiaDiseaseDisorderDorsumEconomicsEducationEducational aspectsEmploymentEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationExposure toFundingGenderGoalsGrantHealthHealth CareIndigenousIndividualLifeLife CycleLife Cycle StagesLife SciencesLinkLong-Term CareLong-term cohort studyLongitudinal StudiesLongitudinal SurveysLongitudinal cohort studyMT-bound tauMeasuresMedicalNational Institutes of HealthNaturePETPET ScanPET imagingPETSCANPETTParticipantParturitionPathologyPersonsPlasmaPlasma SerumPopulation StudyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessProtocolProtocols documentationRaceRacesRacial GroupRad.-PETRandom AllocationRandom SelectionRecordsResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskSamplingSampling StudiesShapesSocial ConditionsSocial SciencesSocial supportSocietal ConditionsSymptomsUnited States National Institutes of HealthVariantVariationVisitWisconsinWomanWorkaccumulated exposureaccumulated long-term exposureactive followupagesaggregate exposurealzheimer riskbasebasesbehavioral healthbio-markersbiologicbiologic markerbiomarkerbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseaseblood-based biomarkerblood-based markercare givingcaregivingcerebral spinal fluidcognitive functioncohortcohort investigationcohort researchcostcumulative exposurecumulative life exposurecumulative long-term exposuredementia riskdifferences due to racedifferences in racediffers by racediffers in raceeconomicethnic differenceethnic diversityethnic subgroupethnically diverseethnicity differenceethnicity groupexposomeextended carefamily supportfollow upfollow-upfollowed upfollowupgender differencegender-associated differenceglobal healthinattentioninattentivenessinsightinvestigate cohortlife courselife-course exposurelifelong exposurelifespan exposurelifetime exposurelong-term studylongitudinal outcome studieslongitudinal research studymenmicrotubule bound taumicrotubule-bound taunovelolder adultolder adulthoodparticipant enrollmentpatient enrollmentphysical conditioningphysical healthpopulation research studypopulation surveypopulation-based studypopulation-level studypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprimary degenerative dementiaprospectiverace based differencesrace differencesrace related differencesracialracial backgroundracial differenceracial diversityracial originracial populationracial subgroupracially differentracially diverseresilienceresilientresponserisk factor for dementiarisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk for dementiarisk of developing Alzheimer'ssenile dementia of the Alzheimer typesexsocialsocial health determinantssocial relationshipssocial support networksocio-economicsocio-economicallysocioeconomicallysocioeconomicsspinal fluidstudy cohortsurvey cohorttautau Proteinstau factortotality of exposuresτ Proteins
Description preview
Abstract
The overarching scientific premise of this application is to evaluate how the accumulation of social advantage
and adversity over the full life course impacts risk and resilience against Alzheimer’s Disease (AD) and Related
Dementias (ADRD). While there is considerable enthusiasm across the social and biological sciences
regarding the…
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