grant
Wiring and rewiring of the chromatin landscape during retinogenesis
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Sept 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20260-11 years oldAffectAnophthalmiaAnophthalmosAssayBRG-1BRG-1 GeneBRG1BRG1 GeneBRM/SWI2-Related Gene-1Basal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBlindnessCase StudyCase-Base StudiesCausalityCell DifferentiationCell Differentiation processCell Growth in NumberCell MultiplicationCell ProliferationCellular ProliferationChildChild YouthChildren (0-21)ChromatinChromatin Remodeling ComplexChromatin Remodeling FactorCommunitiesCompetenceComplexDNADNA BindingDNA Binding InteractionDNA boundDNA mutationDataDeoxyribonucleic AcidDevelopmentDiagnosisDifferentiated GeneDistal Enhancer ElementsENX-1EZH1EZH2EZH2 geneElectroporationElementsEnhancer ElementsEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyEventEye DevelopmentEye diseasesFunctional RNAGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic ChangeGenetic Enhancer ElementGenetic TranscriptionGenetic defectGenetic mutationGenomic approachGenomicsGoalsGrowthHMG-1 DomainHMG-1-Box DomainHMG-BoxHMG-Box DomainsHigh Mobility Group-Box DomainsHumanKMT6KMT6AKO miceKnock-out MiceKnockout MiceKnowledgeLeadMapsMating Type Switching/Sucrose Nonfermenting ProteinMiceMice MammalsMicrophthalmosModern ManMolecularMolecular InteractionMorphogenesisMurineMusMutateMutationMutation AnalysisNeural Stem CellNeurodevelopmental DisorderNeurological Development DisorderNoncoding RNANontranslated RNANucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesNull MouseOutcomePb elementPeptide DomainProcessProductionProtein DomainsRNA ExpressionRegulatory ElementRegulatory RegionsRetinaRetinal DiseasesRetinal DisorderRoleSMARCA4SMARCA4 geneSNF2-BetaSWI/SNF ComplexSWI/SNF Family ComplexSWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4 GeneSightSiteSourceSyndromeTechnologyTertiary Protein StructureTestingTherapeuticTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenic OrganismsUntranslated RNAVisioncase reportcausationcell typecellular differentiationchromatin modifierconditional knock-outconditional knockoutdevelopmentaldevelopmental diseasedevelopmental disorderdisease causationelectroporative deliveryenhancer sequenceepigeneticallyeye disordereye morphogenesisgene electrotransfergene regulatory networkgenetic approachgenetic enhancer sequencegenetic regulatory elementgenetic strategygenome mutationgenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationgenomic effortgenomic strategyheavy metal Pbheavy metal leadhigh definitionhigh-resolutionimprovedin vivoinnovateinnovationinnovativeinsightkidsmalformationmicrophthalmiamorphogenetic processmouse modelmurine modelnanophthalmosnerve stem cellneuralneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodevelopmental diseaseneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornoncodingnovelocular developmentocular diseaseocular disorderontogenyophthalmopathypreventpreventingprogenitor and neural stem cellsprogenitor cell proliferationprogenitor proliferationprogramsrecruitretina diseaseretina disorderretinal neuronretinal progenitorretinal progenitor cellretinal stem cellretinogenesisretinopathysingle cell technologysocial rolespatial and temporalspatial temporalspatiotemporalstem and progenitor cell proliferationstem cell proliferationtranscription factortransgenicvision lossvisual functionvisual lossyoungster
Description preview
SUMMARY: The proper execution of transcriptional programs in retinal progenitor cells is
extremely critical for retinal formation as dysregulation of this process leads to severely
compromised retinogenesis and the development of ocular disorders, including anophthalmia or
microphthalmia. The wiring and rewiring of chromatin landscape constitutes…
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