grant
Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT)
Organization BROAD INSTITUTE, INC.Location CAMBRIDGE, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026Aberrant ChromosomeAffectAgingAgreementAnatomic SitesAnatomic structuresAnatomyAssayBenchmarkingBest Practice AnalysisBioassayBiological AssayBloodBlood Reticuloendothelial SystemBody TissuesCancersCardiovascular DiseasesCatalogsCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosomal DeletionChromosomal OrganizationChromosomal StructureChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome DeletionChromosome OrganizationChromosome StructuresChromosome abnormalityClonal expansion of hematopoietic cellsClonal expansion of hematopoietic stem cellsClonal hematopoietic expansionCodeCoding SystemCollaborationsCommunitiesComputational BiologyCytogenetic AberrationsCytogenetic AbnormalitiesDNADNA DamageDNA InjuryDNA mutationDNA seqDNA sequencingDNAseqDataData AnalysesData AnalysisData SetDeoxyribonucleic AcidDetectionDevelopmentDiseaseDisorderDrynessExposure toFrequenciesFunctional RNAGTExGene ExpressionGenerationsGeneticGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenomicsGenotype-Tissue Expression ProjectGoalsGuidelinesHigh PrevalenceHigh Throughput AssayHistoryHumanHuman BiologyHuman DevelopmentHuman FigureHuman GeneticsHuman bodyIndividualJointsKnowledgeLifeMalignant NeoplasmsMalignant TumorMeasuresModern ManMolecularMosaicismMutagenesisMutagenesis Molecular BiologyMutationNational Institutes of HealthNoncoding RNANontranslated RNANormal TissueNormal tissue morphologyNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesOrganOutcomePartial MonosomyPathogenesisPatternPhenotypePhylogenetic AnalysisPhylogeneticsProcessProductionProteinsProtocolProtocols documentationRNA SeqRNA sequencingRNAseqRecording of previous eventsRegulatory RegionsResearch ResourcesResearch SpecimenResolutionResourcesRoleSamplingScienceSiteSmaHTSomatic Mosaicism across Human TissuesSomatic MutationSpecimenStandardizationStretchingSubcellular ProcessTOPMedTechnologyTissue BanksTissue CollectionTissue ProcurementsTissue SampleTissue repositoryTissuesTrans-Omics for Precision MedicineTreesUnited States National Institutes of HealthUntranslated RNAVariantVariationWorkaccumulated exposureaccumulated long-term exposureage associatedage correlatedage dependentage linkedage relatedage specificaggregate exposurebenchmarkcardiovascular disordercatalogchromosomal defectchromosome defectclonal expansions in the bloodclonal hematopoiesisclones in hematopoietic cellscohortcomputational frameworkcomputer biologycomputer frameworkcumulative exposurecumulative life exposurecumulative long-term exposuredata depositiondata harmonizationdata interpretationdata resourcedata submissiondesigndesigningdevelopmentalexome sequencingexome-seqexperiencefitnessgenetic regulatory elementgenome mutationgenome sequencingharmonized datahematopoietic cell cloneshematopoietic stem cell clonalityhigh throughput screeninghistorieshuman tissueinsightlife historylife spanlife-course exposurelifelong exposurelifespanlifespan exposurelifetime exposuremalignancymosaic diseasesmosaic disordersmultidisciplinaryneoplasm/cancernew technologynoncodingnovelnovel technologiespreservationprogramsrepurposingresolutionsresponsesocial rolesomatic variantsuccesstimelinetissue processingtotality of exposurestranscriptome sequencingtranscriptomic sequencing
Description preview
ABSTRACT: (max 30 lines)
There is an enormous need to create a foundational dataset that will comprehensively catalog somatic
mutations across a diverse range of human tissues, to understand their type, frequency, the cells, and
anatomical compartments in which they are found, and their organizational, functional relationships and
consequences.…
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