grant
Whole Genome Sequencing and Admixture Analyses of Neuropathologic Traits in Diverse Cohorts in USA and Brazil
Organization RUSH UNIVERSITY MEDICAL CENTERLocation CHICAGO, UNITED STATESPosted 15 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDAddressAdmixtureAfricanAfrican ancestryAfrican descentAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaAutopsyBlack PopulationsBlack groupBlack individualBlack peopleBlacksBloodBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemBrain Vascular DisordersBrazilBudgetsCerebrovascular DiseaseCerebrovascular DisordersClinicalClinical DataCognitionCollaborationsCommunitiesCristobaliteDNADataDementiaDeoxyribonucleic AcidEncephalonEuropeanGWA studyGWASGenesGenetic DiversityGenetic VariationGoalsIntracranial Vascular DiseasesIntracranial Vascular DisordersLB diseaseLB disorderLatinoLatino PopulationLatino groupLatino individualLatino peopleLatinosLengthLewy Body DiseaseLewy body disorderLewy diseaseLewy disorderLinkage DisequilibriumMapsMitochondrial DNAMolecularParticipantPathologicPathologyPersonsPhenotypePrimary Senile Degenerative DementiaProteinsResearchSamplingSandSilicaSilicon DioxideSourceTAR DNA-binding protein 43TDP-43TDP43TestingTissuesTridymiteVariantVariationWorkadmixture mappingbrain vascular diseasebrain vascular dysfunctioncausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcerebral vascular diseasecerebral vascular dysfunctioncerebrovascular dysfunctioncohortentire genomefull genomegenome scalegenome sequencinggenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studyhippocampal sclerosisintracranial vascular dysfunctionlow-frequency mutationmtDNAnecropsyneuropathologicneuropathologicalneuropathologynovelpostmortemprimary degenerative dementiaprospectiveprotein TDP-43protein TDP43public health prioritiesrare allelerare mutationrare variantresponsesenile dementia of the Alzheimer typetelomeretraitwhole genomewhole genome association analysiswhole genome association study
Description preview
Identifying molecular drivers of Alzheimer’s disease and related dementias (AD/ADRD) pathologies is an urgent public health priority. This is especially important in persons of African Ancestry. The overall goal of the proposed study is to identify genes and proteins that drive common AD/ADRD pathologic traits. We previously used multi-level omics…
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