grant
Vulnerable and Resilient Cells in Retinal Degeneration
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Mar 2000Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AffectAllelism TestAnimalsApopainApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Caspase 3ApoptoticAppearanceBasic ResearchBasic ScienceBlindnessCASP-3CASP3CASP3 geneCPP-32CPP32CPP32 proteinCPP32BCPP32betaCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell DeathCell SignalingCell SurvivalCell ViabilityCellsCellular biologyCessation of lifeChronicColorComplementation TestCone PhotoreceptorsCranial Nerve IICysteine Protease CPP32Cysteine Protease CPP32 GeneDNA TherapyDNA mutationDataDeathDevelopmentDiseaseDisorderEquilibriumFluorescenceGene ExpressionGene Transfer ClinicalGenesGeneticGenetic ChangeGenetic Complementation TestGenetic DiseasesGenetic InterventionGenetic defectGenetic mutationGrantHistologicHistologicallyHistologyImageIndividualInterventionIntracellular Communication and SignalingKnowledgeLabelLifeLightMeasuresMiceMice MammalsModelingMolecularMolecular FingerprintingMolecular ProfilingMurineMusMutationNamesNerve CellsNerve CrushNerve UnitNeural CellNeurocyteNeuronsOptic NerveOutcomeOutcomes ResearchPARP Cleavage ProteasePARP Cleavage Protease GenePathway interactionsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPigmentary RetinopathyPopulationProcessProgrammed Cell DeathProteinsReagentRecovery of FunctionReporterReportingResearchRetinaRetinal ConeRetinal DegenerationRetinal DiseasesRetinal DisorderRetinal Ganglion CellsRetinitis PigmentosaRodRods and ConesSCA-1SCA-1 GeneSREBP Cleavage Activity 1SREBP Cleavage Activity 1 GeneSecond Cranial NerveSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSynapsesSynapticSystemTapetoretinal DegenerationTestingTherapeuticTherapeutic InterventionTimeTrans TestVertebrate PhotoreceptorsVisualVisual ReceptorYamaYama proteinbalancebalance functionbiological signal transductioncandidate selectioncaspase-3cell biologycell resiliencecell resiliencycellular resiliencecellular resiliencycomplementation analysiscomplementation approachcone cellcone-rod dystrophycysteine protease P32degenerative retina diseasesdevelopmentaleffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsfunctional recoverygain of functiongene repair therapygene therapygene therapy clinical trialgene-based therapygenetic conditiongenetic disordergenetic therapygenome mutationgenomic therapyimagingimaging in vivoimprovedin vivoin vivo imaginginherited retinal degenerationintervention therapyloss of functionmolecular profilemolecular signaturemouse modelmurine modelnamenamednamingnecrocytosisneuronalneuroprotectionneuroprotectivenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayphotoreceptor degenerationpreservationpreventpreventingrepairrepairedresilienceresilientresponseretina degenerationretina diseaseretina disorderretinal degenerativeretinal degenerative diseasesretinal ganglionretinal neuronretinopathyrod and cone dystrophyrod-cone dystrophyscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsurvival outcomesynapsetherapeutically effectivetooltranscriptomicsvision lossvisual loss
Description preview
PROJECT SUMMARY
Inherited retinal degeneration (IRD) is a group of genetic diseases featuring progressive loss of
photoreceptor neurons in the retina and eventual blindness. Affected photoreceptors largely die through
apoptosis that was once thought to be irreversible. However, recent studies in different systems have reported
a phenomenon called…
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