grant
VPS13D, organelle contact, and cellular stress in models of disease
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 15 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20250-11 years oldAcanthocytosisAgeAgingAllelesAllelomorphsAmmon HornAnimalsAtaxiaAtaxyAutophagocytosisBehaviorBehavioralBrainBrain Nervous SystemCarrier ProteinsCell BodyCell Communication and SignalingCell DeathCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseChildChild YouthChildren (0-21)ChoreaChoreic MovementChoreiform MovementCommunicationComplexCoordination ImpairmentCornu AmmonisDNA mutationDefectDegenerative Neurologic DisordersDiseaseDisorderDrosophilaDrosophila genusDyskinesia SyndromesDyssynergiaDystoniaEmbryoEmbryonicEncephalonEndoplasmic ReticulumErgastoplasmExhibitsFailureFibroblastsGene AlterationGene MutationGenesGenetic ChangeGenetic defectGenetic mutationGoalsHealthHeat shock proteinsHippocampusHistologicHistologicallyHumanImpairmentInflammationInflammatoryIntracellular Communication and SignalingIonsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLegs ParalysisLeigh DiseaseLeigh SyndromeLinkLipid TraffickingLipidsLower Extremities ParalysisLower Limbs ParalysisLoxP-flanked alleleMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMiceMice MammalsMitochondriaModelingModern ManMovement Disorder SyndromesMovement DisordersMurineMusMuscle DystoniaMutant Strains MiceMutationNMR ImagingNMR TomographyNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologic DisordersNeurologic ManifestationsNeurologic Signs and SymptomsNeurologic SymptomsNeurologicalNeurological DisordersNeurological ManifestationsNeurological Signs and SymptomsNeuronsNuclear Magnetic Resonance ImagingNull MouseOrganellesPARK6PARK6 genePARK6 proteinPINK1PINK1 genePINK1 gene productPINK1 proteinPTEN induced kinase 1PTEN induced putative kinase 1PTEN-induced putative kinaseParalysis AgitansParaparesisParaplegiaParkinsonParkinson DiseaseParkinson disease 6 genePathway interactionsPatientsPhenotypePhosphatase and tensin homolog induced kinase 1PlayPrimary ParkinsonismProcessProteinsRecessive GenesReportingRoleSeveritiesSignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesStressSubacute Necrotizing EncephalomyelitisSubacute Necrotizing EncephalomyelopathySubacute Necrotizing EncephalopathySubcellular ProcessSymptomsTransport Protein GeneTransport ProteinsTransporter ProteinTremorZeugmatographyage associatedage associated diseaseage associated disorderage associated effectsage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage effectage linkedage relatedage related effectsage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentagesaging effectautophagybehavior phenotypebehavioral phenotypingbiological signal transductioncell stresschild patientsconditional knock-outconditional knockoutcultured cell linedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisease modeldisease phenotypedisorder modelearly onsetfloxedfloxed allelefruit flygene defectgenome mutationhippocampalhuman diseaseimpact of ageinflammation markerinflammatory markerinfluence of agekidslipid exchange proteinlipid transfer proteinlipid transportmitochondrialmitochondrial autophagymouse modelmouse mutantmurine modelmutantmutant allelemutant mouse modelnecrocytosisnerve cell deathnerve cell lossneural manifestationneurodegenerative illnessneurological diseaseneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuropathologicneuropathologicalneuropathologyparaplegicpathwaypediatric patientspostnatalpreventpreventingprotein kinase BRPKprotein kinase BRPK geneserine/threonine-protein kinase PINK1social rolespasticitystress proteinyoungster
Description preview
ABSTRACT
Organelle contact and communication are important for the health of cells. Alteration of the
relationship between organelles, such as endoplasmic reticulum (ER) and mitochondria,
influences the transfer of ions, lipids, and proteins, impacts inter-organelle dynamics and is
associated with diseases. Our hypothesis is that defects in…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click