grant
Volitional Control of the Nonhuman Primate Lower Limbs
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AnimalsAreaAutomobile DrivingBMIBMI percentileBMI z-scoreBicyclingBody mass indexCell Communication and SignalingCell SignalingCommunicationComplexConsensusCortical CordCuesCyclicityDevelopmentDimensionsE-stimEEGElectric StimulationElectroencephalogramElectroencephalographyElectromyographyExtremitiesGA733GaitGastrointestinal Tumor-Associated Antigen 1, 40-KD GlycoproteinGoalsHealthHindlimbHumanImplantInterventionIntracellular Communication and SignalingLegLimb structureLimbsLocomotionLower ExtremityLower LimbM1S1MaintenanceMapsMechanicsMedulla SpinalisMembrane Component, Chromosome 1, Surface Marker 1Membrum inferiusMicroelectrodesMiniaturized ElectrodesModern ManMonitorMotionMotorMotor CortexMovementMuscleMuscle TissueNerve CellsNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeurosciencesNeurostimulation procedures of spinal cord tissueNon-TrunkOutputPalsyParalysedPathway interactionsPeriodicityPersonsPhasePlantsPlayPlegiaPrimatesPrimates MammalsPyramidal TractsQuetelet indexR-Series Research ProjectsR01 MechanismR01 ProgramReflexReflex actionResearchResearch GrantsResearch Project GrantsResearch ProjectsRhythmicityRoleSignal TransductionSignal Transduction SystemsSignalingSkeletal MuscleSpeedSpinalSpinal CordSpinal Cord StimulationSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injuryStreamTACSTD2TACSTD2 geneTestingTimeTrainingTraumatic MyelopathyTumor-Associated Calcium Signal Transducer 2VisualVoluntary MuscleWalkingWorkbiological signal transductionbody movementbrain machine interfacecentral pattern generatordevelopmentaldrivingelectrostimulationlinear maplinear transformationmechanicmechanicalmuscularneuralneuronalnon-human primatenonhuman primateparalysisparalyticpathwayrestorationskillssocial roletranslational applicationstreadmillvirtual environmentwireless
Description preview
SUMMARY
The ability to modify ongoing gait with precise, voluntary adjustments is what allows animals to navigate
complex terrains and to execute skilled actions during ongoing pursuits. However, how the nervous system
generates the signals to precisely control the lower limbs while simultaneously maintaining ongoing locomotion
is still poorly…
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