grant
Virus breathing and assembly-disassembly transitions in host-entry
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AntibodiesBiophysicsBreathingCell BodyCellsChemistryCommunicable DiseasesComplexCoxsackie VirusesCoxsackievirusCryo-electron MicroscopyCryoelectron MicroscopyDNA VirusesDengueDetectionElectron CryomicroscopyEndocytosisEnvironmentFlavivirusGenomeGoalsGroup B ArbovirusHPVHealthHumanHuman Papilloma VirusHuman PapillomavirusImmune systemIndividualInfectious DiseasesInfectious DisorderInfectious Human Wart VirusLife CycleLife Cycle StagesMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingModelingModern ManMolecular ConfigurationMolecular ConformationMolecular StereochemistryMonitorNon-Polyadenylated RNAOrthoflavivirusOutcomePathogenicityProteinsRNARNA Gene ProductsRNA VirusesReceptor CellReceptor ProteinResearchRespiratory AspirationRespiratory InspirationRibonucleic AcidStructureTherapeutic antibodiesViralViral DiseasesViral GenomeVirionVirusVirus AssemblyVirus DiseasesVirus ParticleVirus ReplicationZIKAbiophysical foundationbiophysical principlesbiophysical sciencesconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopyhuman pathogenimprovedinsightinspirationlife coursemonomerparticleprogramsreceptorreceptor bindingreceptor boundresponsesmall moleculeviral assemblyviral infectionviral multiplicationviral replicationvirus genomevirus infectionvirus multiplicationvirus-induced diseasewart virus
Description preview
Project Summary
Viruses are serious human pathogens and viral infectious diseases represent a continuing challenge for global
human health. The long-term focus of my research program is to uncover host-induced changes in pathogenic
human viral dynamics by targeting the first critical steps of virus entry into human host cells. Our specific focus…
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