grant
Virologic and immunologic impacts of active viral persistence in lung AMs of HIV-1-infected, cART-suppressed individuals
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 17 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AddressAffectAlveolar MacrophagesAssayBindingBioassayBiologicalBiological AssayBloodBlood PlasmaBlood Reticuloendothelial SystemBlood monocyteBody TissuesBrainBrain Nervous SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Death InductionCell SurvivalCell ViabilityCellsCellular Immune FunctionChronicClonalityCo-cultureCocultivationCocultureCoculture TechniquesDataDisease ProgressionDisease remissionDysfunctionEffector CellEncephalonEvolutionFISH TechnicFISH TechniqueFISH analysisFISH assayFeedbackFluorescence In Situ HybridizationFluorescent in Situ HybridizationFrequenciesFunctional disorderGene TranscriptionGenetic TranscriptionHIV cureHIV functional cureHIV infection persistenceHIV persistenceHIV replicationHIV viral persistenceHIV viral replicationHIV-1HIV-1 cureHIV-1 functional cureHIV-1 persistenceHIV-1 replicationHIV-1 viral replicationHIV-1 virus replicationHIV-IHIV/AIDS cureHIV1Hortega cellHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human immunodeficiency virus 1ImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsIndividualInterruptionKineticsKnowledgeKupffer CellsLengthLiverLungLung Respiratory SystemLymphoid CellMacrophageMacrophage ActivationMarrow monocyteMethodsMicrogliaModern ManMolecularMolecular InteractionMolecular TargetMyelogenousMyeloidMyeloid CellsMφNatureNon-Polyadenylated RNAORFsOpen Reading FramesPhagocytosisPhysiopathologyPlasmaPlasma SerumPopulationProductionProductivityProtein Coding RegionProvirusesPulmonary MacrophagesRNARNA ExpressionRNA Gene ProductsRNA SplicingRelapseRemissionReportingResidualResidual stateReticuloendothelial System, Serum, PlasmaRibonucleic AcidRoleSIVSimian Immunodeficiency VirusesSortingSplicingStellate Sinusoidal MacrophageStimulusSubgroupT-CellsT-LymphocyteT4 CellsT4 LymphocytesTissuesTranscriptTranscriptionTranslationsTreatment PeriodViralViral Gene ProductsViral Gene ProteinsViral ProteinsViral reservoirViremiaVirionVirusVirus ParticleVirus ReplicationVirus reservoirantiretroviral therapyantiretroviral treatmentbiologiccell typeco-morbidco-morbiditycohortcomorbiditycomparativecytokinecytotoxicexhaustiongenetic make-upgenetic makeupgitter cellhepatic body systemhepatic organ systemhuman immunodeficiency virus curehuman immunodeficiency virus persistencehuman immunodeficiency virus replicationhuman immunodeficiency virus-1 replicationhuman subjectimmune activationimmune functionliver macrophageloss of functionmesogliamicroglial cellmicrogliocytemonocytepathophysiologyperipheral bloodperivascular glial cellpersistent HIVpersistent HIV-1persistent human immunodeficiency viruspreventpreventingsocial rolesuccessthymus derived lymphocytetranscriptomicstranslationtreatment daystreatment durationviraemiaviral RNAviral multiplicationviral reboundviral replicationviral sepsisvirus RNAvirus multiplicationvirus proteinvirus reboundvirusemia
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Project Summary / Abstract
Persistence of HIV-1 in tissue reservoirs of therapy-suppressed, aviremic individuals is a major challenge
to HIV-1 cure. The viral reservoir consists of myeloid and lymphoid cells that harbor the virus through long periods
of combination anti-retroviral therapy (cART). Until recently, it was thought that HIV-1 provirus…
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