grant
Virologic and immunologic impacts of active viral persistence in lung AMs of HIV-1-infected, cART-suppressed individuals
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 17 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AddressAffectAlveolar MacrophagesAssayBindingBioassayBiologicalBiological AssayBloodBlood PlasmaBlood Reticuloendothelial SystemBlood monocyteBody TissuesBrainBrain Nervous SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Death InductionCell SurvivalCell ViabilityCellsCellular Immune FunctionChronicClonalityCo-cultureCocultivationCocultureCoculture TechniquesDataDisease ProgressionDisease remissionDysfunctionEffector CellEncephalonEvolutionFISH TechnicFISH TechniqueFISH analysisFISH assayFeedbackFluorescence In Situ HybridizationFluorescent in Situ HybridizationFrequenciesFunctional disorderGene TranscriptionGenetic TranscriptionHIV-1HIV-IHIV1Hortega cellHumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1ImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsIndividualInterruptionKineticsKnowledgeKupffer CellsLengthLiverLungLung Respiratory SystemLymphoid CellMacrophageMacrophage ActivationMarrow monocyteMethodsMicrogliaModern ManMolecularMolecular InteractionMolecular TargetMyelogenousMyeloidMyeloid CellsMφNatureNon-Polyadenylated RNAORFsOpen Reading FramesPhagocytosisPhysiopathologyPlasmaPlasma SerumPopulationProductionProductivityProtein Coding RegionProvirusesPulmonary MacrophagesRNARNA ExpressionRNA Gene ProductsRNA SplicingRelapseRemissionReportingResidualResidual stateReticuloendothelial System, Serum, PlasmaRibonucleic AcidRoleSIVSimian Immunodeficiency VirusesSortingSplicingStellate Sinusoidal MacrophageStimulusSubgroupT-CellsT-LymphocyteT4 CellsT4 LymphocytesTissuesTranscriptTranscriptionTranslationsTreatment PeriodViralViral Gene ProductsViral Gene ProteinsViral ProteinsViral reservoirViremiaVirionVirusVirus ParticleVirus ReplicationVirus reservoirantiretroviral therapyantiretroviral treatmentbiologiccell typeco-morbidco-morbiditycohortcomorbiditycomparativecytokinecytotoxicexhaustiongenetic make-upgenetic makeupgitter cellhepatic body systemhepatic organ systemhuman subjectimmune activationimmune functionliver macrophageloss of functionmesogliamicroglial cellmicrogliocytemonocytepathophysiologyperipheral bloodperivascular glial cellpreventpreventingsocial rolesuccessthymus derived lymphocytetranscriptomicstranslationtreatment daystreatment durationviraemiaviral RNAviral multiplicationviral reboundviral replicationviral sepsisvirus RNAvirus multiplicationvirus proteinvirus reboundvirusemia
Description preview
Project Summary / Abstract
Persistence of HIV-1 in tissue reservoirs of therapy-suppressed, aviremic individuals is a major challenge
to HIV-1 cure. The viral reservoir consists of myeloid and lymphoid cells that harbor the virus through long periods
of combination anti-retroviral therapy (cART). Until recently, it was thought that HIV-1 provirus…
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