grant
Viral insulin-like peptides and their unique activities on mammalian insulin/IGF-1 system
Organization BOSTON COLLEGELocation CHESTNUT HILL, UNITED STATESPosted 17 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureAcromegalyAcuteAdeno-Associated VirusesAdult-Onset Diabetes MellitusAffectAffinity ChromatographyAgonistAssayAssociated VirusesBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBloodBlood Reticuloendothelial SystemBlood SerumBody TissuesBreast Cancer ModelBreast tumor modelC-PeptideCancer PatientCancersCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessChronicChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalCollectionComplexCryo-electron MicroscopyCryoelectron MicroscopyDNADataDeoxyribonucleic AcidDependoparvovirusDependovirusDevelopmentDiabetic Kidney DiseaseDiabetic NephropathyDiseaseDisorderElectron CryomicroscopyEndocrine Gland SecretionFamilyFc ReceptorFellowshipFishesFrog VirusesGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGoalsGrantGraves ophthalmopathyGraves' eye diseaseGrowthGrowth DisordersGrowth Hormone Insensitivity SyndromeGrowth Hormone Receptor DefectHeterograftHeterologous TransplantationHormonesHumanHumulin RIGF Type 1 ReceptorIGF-1IGF-1 ReceptorIGF-IIGF-I ReceptorIGF-I-SmCIGF1RIGF1R geneImpairmentIn VitroInappropriate GH Secretion Syndrome (Acromegaly)Inappropriate Growth Hormone Secretion Syndrome (Acromegaly)InfusionInfusion proceduresInjectionsInsulinInsulin AntagonistsInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin ResistanceInsulin-Dependent Tyrosine Protein KinaseInsulin-Like Growth Factor 1Insulin-Like Growth Factor 1 ReceptorInsulin-Like Growth Factor 1 Receptor GeneInsulin-Like Growth Factor IInsulin-Like Growth Factor Type 1 ReceptorInsulin-Like Growth FactorsInsulin-Like Somatomedin Peptide IInsulin-Like-Growth Factor I ReceptorIntermediary MetabolismIntracellular Communication and SignalingIridoviridaeKetosis-Resistant Diabetes MellitusKnowledgeLabelLaron DwarfismLaron SyndromeLaron Type Dwarfism ILigandsLiverMalignant NeoplasmsMalignant TumorMammaliaMammalsMapsMaturity-Onset Diabetes MellitusMediatingMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMolecularMolecular InteractionMolecular TargetMurineMusNIDDKNIDDMNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityOrganPeptide-based drugPeptidesPlayPostdocPostdoctoral FellowPrimary GH ResistancePrimary Growth Hormone ResistanceProductionProliferatingProteinsProteomicsRanavirusReceptor InhibitionReceptor ProteinReceptor SignalingRegular InsulinResearchResearch AssociateRoleSatellite VirusesSerumSevere GH InsensitivitySignal PathwaySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSomatomedin CSomatomedinsSomatotropin Hypersecretion Syndrome (Acromegaly)Stable Diabetes MellitusStructureStructure-Activity RelationshipSubcellular ProcessSulfation FactorSystemT2 DMT2DT2DMTechniquesTestingTherapeutic HormoneThyroid-Associated OphthalmopathyTimeTissue GrowthTissuesTranscription Factor Proto-OncogeneTranscription factor genesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVena caval structureVenae CavaeViralViral DiseasesVirusVirus DiseasesWorkXenograftXenograft procedureXenotransplantationacromegalic featuresadeno associated virus groupadiposityadult onset diabetesaffinity purificationantagonismantagonistanti-cancer researchantibody receptorbiological signal transductionbovine growth hormonebovine somatotropincancer progressioncancer researchcell growthchemical structure functionchemical synthesischronic kidney diseaseconnecting peptidecorpulencecryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldysthroid orbitopathydysthyroid eye diseasedysthyroid ophthalmopathydysthyroid orbitopathyendocrine ophthalmopathyendocrine orbitopathyexperimentexperimental researchexperimental studyexperimentsglucose metabolismglucose toleranceglucose uptakehepatic body systemhepatic organ systemhuman diseasehypoimmunityimmune deficiencyimmunodeficiencyin vivoin vivo Modelinfusionsinhibitorinnovateinnovationinnovativeinsightinsulin inhibitorinsulin resistantinsulin sensitivityinsulin signalinginsulin toleranceinsulin-like peptideinsulinlike growth factorketosis resistant diabetesmalignancymammary cancer modelmammary tumor modelmaturity onset diabetesmemberneoplasm progressionneoplasm/cancerneoplastic progressionnovelontogenyophthalmic Graves diseaseoverexpressoverexpressionpeptide drugphospho-proteomicsphosphoproteomicspost-docpost-doctoralpost-doctoral traineepromoterpromotorreceptorreceptor expressionreceptor functionrecruitresearch associatessocial rolesomidobovestructure function relationshiptherapeutic peptidethree dimensional structurethyroid associated ophthalmopathiesthyroid eye diseasethyroid ophthalmopathythyroid orbitopathytooltranscription factortumortumor progressiontype 2 DMtype II DMtype two diabetesvena cavaviral infectionvirus infectionvirus-induced diseasexeno-transplantxeno-transplantation
Description preview
PROJECT SUMMARY/ABSTRACT
In mammals, insulin primarily regulates metabolism while insulin-like growth factor-1 (IGF-1) stimulates growth,
proliferation and differentiation. Aberrant production of IGF-1 is connected with different human diseases
including growth disorders such as Laron syndrome, acromegaly and Graves' orbitopathy as well as thyroid…
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