grant
Vibrational Sensing in Super-Resolution Two-Dimensional Infrared Imaging
Organization UNIVERSITY OF DELAWARELocation Newark, UNITED STATESPosted 1 Jun 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY20252-dimensionalAD dementiaAddressAffectAffinityAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimers DementiaAmino AcidsAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAmyloidosisAssayAβBindingBioassayBiologic ModelsBiologicalBiological AssayBiological ModelsBiophysicsBody TissuesBoronCOBRECardiomyopathiesCenter of Biomedical Research ExcellenceCenters of Research ExcellenceChaperoneClosure by LigationCollaborationsComplexCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderCryo-electron MicroscopyCryoelectron MicroscopyCrystallinsDataDesminDetectionDevelopmentDiabetes MellitusDiseaseDisorderDrugsElectron CryomicroscopyFutureGeneralized GrowthGenetic PolymorphismGoalsGranulomatous EnteritisGrowthHSP27HSPB1HSPB1 geneHeat Shock 27 kD Protein 1Heat Shock 27kD Protein 1 GeneHeat Shock Protein 27Heat shock proteinsHeat-Shock Protein 27 GeneHeterogeneityHourImageImaging DeviceImaging InstrumentImaging ProceduresImaging TechnicsImaging TechniquesImaging ToolIndividualInvestigationIsotope LabelingKineticsLabelLaser ElectromagneticLaser RadiationLasersLigationMeasurementMeasuresMedicationMethodsMicroscopeMicroscopyModel SystemModelingMolecular ChaperonesMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMyocardial DiseasesMyocardial DisorderMyocardiopathiesPeptide FragmentsPeptidesPharmaceutical PreparationsPolymorphPopulationPredispositionPreparationPrimary Senile Degenerative DementiaProteinsR-Series Research ProjectsR01 MechanismR01 ProgramResearchResearch GrantsResearch Project GrantsResearch ProjectsResolutionRoleSamplingSecondary Protein StructureSkeletinSpectroscopySpectrum AnalysesSpectrum AnalysisSpinal ColumnSpineStructureSusceptibilitySystemTechniquesTechnologyTestingTissue GrowthTissuesVertebral columnViral DiseasesVirus DiseasesWorka beta peptideabetaaminoacidamyloid betaamyloid diseaseamyloid imagingamyloid peptideamyloid-b proteinbackbonebeta amyloid fibrilbio-imagingbioimagingbiologicbiophysical foundationbiophysical principlesbiophysical sciencesconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydesigndesigningdevelopmentaldiabetesdrug/agenteleocolitisimage-based methodimagingimaging methodimaging modalityimprovedinnovateinnovationinnovativeinstrumentlens proteinmyocardium diseasemyocardium disordernew technologynovel technologiesontogenypeptide structurepolymorphismpreparationsprimary degenerative dementiaprotein structureprotein structuresproteins structureregional enteritisresolutionssenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteinspatial and temporalspatial temporalspatiotemporalstress proteinsuper high resolutionsuperresolutiontemporal measurementtemporal resolutiontime measurementtooltwo-dimensionalultra high resolutionviral infectionvirus infectionvirus-induced disease
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Project Summary
Vibrational Sensing in Super-Resolution Two-Dimensional Infrared Imaging
Many amyloidogenic peptides are implicated in diseases ranging from Alzheimer’s to diabetes to
cardiomyopathy. Chaperone proteins such as HSP27 and αB-crystallin serve a protective role by interacting
with amyloidogenic peptides to protect against amyloid…
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