grant
Veverimer to decrease net acid excretion and bone resorption in adults with osteopenia: a dose-finding randomized controlled trial
Organization TUFTS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 10 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years oldACE InhibitorsAcid-Base BalanceAcid-Base EquilibriumAcidsAdultAdult HumanAdverse effectsAgeAlkaliesAngiotensin I-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme AntagonistsAngiotensin-Converting Enzyme InhibitorsAnimalsAnti-Hypertensive AgentsAnti-Hypertensive DrugsAnti-HypertensivesArchitectureBaking SodaBicarbonatesBindingBlood SerumBone FormationBone ResorptionBuffersC-telopeptideCO2CTXCYCLO-cellCapsulesCarbon DioxideCarbonic Acid Monosodium SaltCarbonic AnhydrideCarloxanCerealsChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCiclofosfamidaCiclofosfamideCicloxalClafenClapheneClinicalClinical TrialsConduct Clinical TrialsConsumptionCycloblastinCycloblastineCyclophosphamCyclophosphamideCyclophosphamidumCyclophosphanCyclophosphaneCyclophosphanumCyclostinCyclostineCytophosphanCytophosphaneCytoxanDataDevelopmentDietDisease ProgressionDoseDrugsEndoxanEndoxanaEnduxanEngineering / ArchitectureExcretory functionFecesFosfaseronFutureG Protein-Coupled Receptor 68GPR68GPR68 geneGenoxalGenuxalGlassGlomerular Filtration RateGrainH+ elementHCO3Hydrochloric AcidHydrogen CarbonatesHydrogen ChlorideHydrogen IonsHydrogen OxideHyperpotassemiaHypertensionHypotensive AgentHypotensive DrugsImpairmentIngestionIntakeIntermediary MetabolismIntestinalIntestinesK elementKHCO3KidneyKidney Urinary SystemKininase II AntagonistsKininase II InhibitorsLaboratoriesLedoxinaMeasuresMedicationMetabolic ProcessesMetabolic acidosisMetabolismMethodsMitoxanModernizationMolecular InteractionMuriatic AcidN-terminalNH2-terminalNa elementNeosarOGR1OralOsteoclastic Bone LossOsteoclastsOsteogenesisOsteopeniaOsteoporosisOsteoporotic riskOutcomeOvarian Cancer G Protein-Coupled Receptor 1ParticipantPharmaceutical PreparationsPhasePlacebosPlant ResinsPolymersPopulationPotassiumProcessProcess AssessmentProcytoxProductionProteinsProtonsRandomizedRandomized Controlled Clinical TrialsRandomized, Controlled TrialsReceptor ProteinRecommendationRenal functionRiskSafetySaltsSample SizeScheduleSendoxanSerumSham TreatmentSodiumSodium BicarbonateSodium Hydrogen CarbonateStomachSyklofosfamidTestingTubularTubular formationType I ProcollagenUrineVascular Hypertensive DiseaseVascular Hypertensive DisorderWaterZytoxanadult youthadulthoodage associatedage associated declineage correlatedage dependentage dependent declineage linkedage relatedage related declineage specificagesanti-hypertensionbonebone cellbone healthbone lossbone massbone tissue formationbowelcapsulechronic kidney diseasedecline with agedesigndesigningdevelopmentaldietarydietary excessdietary guidelinesdietsdrug/agentexcretionfallsfracture riskfruits and vegetablesgastricgastrointestinalgastrointestinal symptomhigh blood pressurehigh riskhyperkalemiahyperpiesiahyperpiesishypertensive diseasehypertensive disorderingestkidney functionlater in lifelater lifemid lifemid-lifemiddle agemiddle agedmidlifenovelolder adultolder adulthoodosteoporosis riskpolymerpolymericpotassium bicarbonatepotassium hydrocarbonatepreservationpreventpreventingrandomisationrandomizationrandomized control clinical trialrandomized control trialrandomly assignedreceptorrecruitrenalresinresponserisk developing osteoporosisrisk factor for osteoporosissham therapystoolurinarywestern dietwestern-style dietwestern-type dietyoung adultyoung adult ageyoung adulthood
Description preview
PROJECT SUMMARY
Starting in mid-life, bone resorption rises and exceeds bone formation – a process that leads to progressive loss
of bone mass, destruction of bone architecture, and ultimately an increased risk of fracture later in life. Acid-
producing diets, such as the modern Western diet, have been implicated as contributors to increased bone…
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