grant
Vesicle-mediated drug resistance of Candida albicans biofilm
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 15 Jun 2008Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AnimalsAssayBackBasal Transcription FactorBasal transcription factor genesBioassayBiogenesisBiological AssayBiological FunctionBiological ProcessBiologyCandidaCandida albicans resistanceCandida albicans resistantCell BodyCell SurvivalCell ViabilityCell-Extracellular MatrixCellsClinicalCollaborationsComplexDefectDorsumDrug TargetingDrug TherapyDrug resistanceDrugsECMEndosomesExhibitsExtracellular MatrixFluconazoleFundingFungal Drug ResistanceFungus DiseasesFungus drug resistantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticInfectionInvestigationLibrariesLifeLinkMediatingMedical DeviceMedicationMicrobial BiofilmsModelingMoniliaMycosesOrigin of LifePathogenesisPathway interactionsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhenotypePredispositionProductionProteomicsReceptosomesRegulatory PathwayResearchResistanceRoleSortingSurfaceSusceptibilityTechnologyTestingTherapeutic FungicidesTranscription Factor Proto-OncogeneTranscription factor genesVesicleVirulenceanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantbiofilmbiofilm communitybiomedical implantcandida biofilmcell communitycellular communitydiflucandrug interventiondrug resistantdrug treatmentdrug/agenteffective therapyeffective treatmentextracellular vesiclesfungal infectionfungus drug resistancefungus infectiongene networkgenetic effectorimplant deviceimplantable devicein vivoindwelling deviceinnovateinnovationinnovativeinsightloss of functionmixed species biofilmmortalitymulti-microorganism biofilmmultispecies biofilmmutantnovelpathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspolymicrobial biofilmpreservationpublic health relevanceresistance mechanismresistance to Drugresistance to anti-fungalresistantresistant mechanismresistant to Drugresistant to anti-fungalskillssocial roletooltranscription factortranscriptomics
Description preview
Project Summary
Candida commonly adhere to medical devices, flourishing as a biofilm. A clinical hallmark of biofilm infection is
profound antifungal resistance. As effective therapies are not available for these life-threatening infections,
understanding how the cells survive existing drug therapies is desperately needed. The extracellular…
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