grant
Vascular regulation of fatty acid transport in metastatic tumor outgrowth
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AffectAmino AcidsAntibodiesAntigensAutomobile DrivingBODIPYBackBindingBiomassBlood Vessel TumorBlood VesselsBreast PDX modelsCD36CD36 geneCancer TreatmentCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellsCellular ProliferationClinicCollaborationsConfocal MicroscopyD-GlucoseDataDetectionDevelopmentDextroseDistantDorsumDoseDysfunctionEndothelial CellsEndotheliumFABP11FABP3FABP3 geneFLK1FLT VEGF ReceptorFLT1 RTKFLT1 Receptor Tyrosine KinaseFatty Acid Metabolism PathwayFatty Acid-Binding Protein 3 GeneFatty AcidsFlt-1FluorescenceFunctional disorderFutureGP3BGP4GPIVGlnGlucoseGlutamineHFABPHexadecanoatesHumanImmuneImmune mediated therapyImmunesImmunologically Directed TherapyImmunotherapyIn SituInhibition of Cell ProliferationIntermediary MetabolismIntracellular Communication and SignalingKDR geneKnock-outKnockoutL-GlutamineLipidsLocationLoxP-flanked alleleLungLung Respiratory SystemMALD-MSMALDIMALDI-MSMDGIMDGI GeneMFABPMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolicMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModelingModern ManMolecular InteractionMurineMusNegative Control of Cell ProliferationNegative Regulation of Cell ProliferationNeoplasm MetastasisNeoplasms in Vascular TissueNutrientNutritional RequirementsO-FABPOrganPDX modelPalmitatesPatient derived xenograftPatient-derived xenograft models of breast cancerPhysiopathologyPlayPolyunsaturated Fatty AcidsPopulationProductionProto-Oncogene Protein fltQ LevoglutamideQ. LevoglutamideRNA SeqRNA sequencingRNAseqReceptor Tyrosine Kinase,Class VRegulationRoleSCARB3Secondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpectroscopy, Mass, Matrix-Assisted Laser Desorption-IonizationStreamSurface ProteinsSystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyTIRF MicroscopyTechniquesTechnologyTestingTotal Internal Reflection FluorescentTotal Internal Reflection Fluorescent MicroscopyTrans Fatty AcidsTransportationTumor CellTyrosine Protein Kinase FRTTyrosine Protein Kinase Receptor FLTVEGF Receptor flt-1 ProteinVEGF ReceptorsVEGFRVEGFR-1VEGFR-2VEGFR1VEGFR2VPF ReceptorVascular Endothelial CellVascular Endothelial Cell Growth Factor ReceptorVascular Endothelial Growth Factor Receptor 2Vascular Endothelial Growth Factor Receptor-1Vascular EndotheliumVascular NeoplasmsVascular Permeability Factor ReceptorVascular SystemVascular Tissue TumorVascular TumorWorkadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyaminoacidanti-cancer therapybiological signal transductionblood vessel neoplasmbreast cancer PDXbreast cancer patient-derived xenograftcancer cellcancer metastasiscancer microenvironmentcancer therapycancer-directed therapychemotherapydevelopmentaldrivingfatty acid metabolismfatty acid transportfatty acid-transport proteinfloxedfloxed allelefms-Like Tyrosine Kinaseimaging mass spectrometryimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimprovedin vivoinnovateinnovationinnovativelong chain fatty acidmass spectrometric imagingmatrix assisted laser desorption ionizationmetabolism measurementmetabolomicsmetabonomicsmouse modelmurine modelneoplastic cellneutralizing antibodynutrient requirementpathophysiologypatient derived xenograft modelsocial roletherapeutic T-cell platformthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtumortumor cell metastasistumor microenvironmentuptakevascular
Description preview
Project Summary
Tumor metastasis requires supportive microenvironment for outgrowth of disseminated tumor
cells. The switch of metastatic cells from dormant to proliferative state needs nutrients for
energetics and biomass production. Although metabolic regulation of tumor metastasis is not well-
established, recent studies demonstrated the…
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