grant
Validation of electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention
Organization LIEBER INSTITUTE, INC.Location BALTIMORE, UNITED STATESPosted 10 Jul 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AffectAmphetaminesAnatomic SitesAnatomic structuresAnatomyAnteriorArousalAssayAttentionAttentional deficitBehaviorBehavior ControlBehavioralBehavioral ManipulationBioassayBiological AssayBiological MarkersBrain DiseasesBrain DisordersCausalityCell Communication and SignalingCell SignalingCognitiveCommon Rat StrainsConflictConflict (Psychology)CuesDataDesoxynorephedrinDetectionDevelopmentDorsalEEGElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)Encephalon DiseasesEnhancersEtiologyFeedbackFrequenciesFunctional MRIFunctional Magnetic Resonance ImagingGoalsHumanImpairmentIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersLengthLinkLiteratureLocus CoeruleusMachine LearningMeasuresMental disordersMental health disordersMiceMice MammalsMissionModern ManMurineMusNational Institutes of HealthNatureNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurobiologyNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNucleus Pigmentosus PontisPatientsPerformancePhasePhenaminePhenoprominProcessProductionProtocolProtocols documentationPsychiatric DiseasePsychiatric DisorderQOLQuality of lifeRatRats MammalsRattusReaction TimeResponse RTResponse TimeRodentRodentiaRodents MammalsRoleSignal TransductionSignal Transduction SystemsSignalingStimulusStructureSymptomsTestingTimeTranslationsUnited States National Institutes of HealthValidationaddiction liabilityaddiction potentialattentive deficitaxon signalingaxon-glial signalingaxonal signalingbehavior measurementbehavioral controlbehavioral measurebehavioral measurementbio-markersbiologic markerbiological signal transductionbiomarkerbiomarker identificationblue nucleuscausationcingulate cortexdesigndesigningdevelop therapydevelopmentaldisease causationdl-Amphetamineearly screeningelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfMRIfunctional outcomesglia signalingglial signalingidentification of biomarkersidentification of new biomarkersimprovedin vivoinnovateinnovationinnovativeinsightintervention developmentlocus ceruleus structuremachine based learningmarker identificationmental illnessmodel organismnerve signalingneuralneural circuitneural circuitryneural patterningneural signalingneurobiologicalneurocircuitryneuronalneuronal signalingneurophysiologicalneurophysiologyneuropsychiatric diseaseneuropsychiatric disorderneurotransmissionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-human primatenonhuman primatenovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyperformance testspre-clinicalpreclinicalpsychiatric illnesspsychological disorderpsychomotor reaction timepsychostimulantrecruitresponseside effectsocial rolesustained attentionsynaptic circuitsynaptic circuitrytherapy developmenttouch paneltouch screentouch screen paneltouchscreentouchscreen paneltranslationtranslational studytreatment developmentvalidationsvigilance
Description preview
PROJECT SUMMARY
Sustained attention, the ability to focus on an activity or stimulus over time, is impaired in many brain disorders.
Targeting attentional deficits for treatment is critical because these symptoms are negatively correlated with
functional outcome and quality of life. Continuous performance tests (CPTs) have been designed to measure…
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