grant
Vaginal Microbiome, Inflammatory Mediators, Metabolome, and Dysmenorrhea Symptom-based Phenotypes
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 15 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202516S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seqAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryArachidonic AcidsBacteriaBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiological MarkersBiological Response ModifiersBiomodulatorsBlood SampleBlood specimenConditioning TherapyDataDrug usageDrugsDysmenorrheaEndocrine Gland SecretionEndometritisFemaleFunctional MetagenomicsFundingGardnerellaGeneral TaxonomyGenesGoalsGonadal Steroid HormonesGynecologicHealthHormonalHormonesHourHysterectomyImmune MediatorsImmune Mediators/ModulatorsImmunoassayIndividualIndividual DifferencesInflammationInflammation MediatorsInflammatoryInflammatory ResponseLactobacillusLinkLong-term prospective studiesMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMensesMenstrual PainMenstruationMetagenomicsMethodsNational Institutes of HealthNetwork-basedPainPainfulPainful MenstruationParticipantPathway interactionsPersonsPharmaceutical PreparationsPhenotypePilot ProjectsPrevotellaProbioticsProstaglandinsProstanoidsQOLQuality of lifeQuestionnairesResearchResearch ResourcesResourcesRiskRisk FactorsRoleSamplingSchoolsSex HormonesSex Steroid HormonesShort-Chain Fatty AcidsShotgunsSwabSymptomsSystems BiologyTaxonomyTestingTherapeutic HormoneUnited States National Institutes of HealthVaginaVolatile Fatty AcidsWomanWorkagedbehavior interventionbehavioral interventionbio-markersbiologic markerbiomarkerchildbearing agechronic pain conditionchronic pain disorderchronic painful conditioncomputer based predictioncytokinedrug usedrug/agentexperiencefallsfemale reproductive healthfertile agegenital tractgirlsgonadal steroidsimprovedindividual heterogeneityindividual variabilityindividual variationinflammation markerinflammatory markerinflammatory mediatorlongitudinal, prospective studymenstrual periodmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmetagenome sequencingmetagenomic sequencingmicrobialmicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremonthly periodmonthly periodsmultiomicsmultiple omicsopiate consumptionopiate drug useopiate intakeopiate useopioid consumptionopioid drug useopioid intakeopioid usepain reductionpanomicspathwaypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpilot studypredictive modelingracial diversityracially diverserecruitreduce painreproductive agereproductive health among femalesreproductive health among womenreproductive health in femalesreproductive health in womenreproductive tractreproductive yearssex steroidshot gunsocial rolestandard carestandard treatmentvaginal biomevaginal floravaginal lactobacillivaginal microbial communityvaginal microbiomevaginal microbiotavaginal microflorawomen's reproductive health♀
Description preview
PROJECT SUMMARY
Dysmenorrhea is a prevalent pain condition and a risk factor for developing other chronic pain conditions.
Dysmenorrhea experiences vary significantly among individual women. Some women are symptom-free, and
those with symptoms fall into three dysmenorrhea symptom phenotypes: mild localized pain, severe localized
pain, and multiple…
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