grant
Vaccine strategies for HIVAIDS
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDS VirusALVACALVAC Canarypox VectorATAC sequencingATAC-seqATACseqATRAAcid CarboxypeptidaseAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAdjuvantAffectAffinityAgonistAlum AdjuvantAnimalsAntibiotic AgentsAntibiotic DrugsAntibioticsAntibodiesAntigenic DeterminantsAntigensAntiheparin FactorAntineoplastic VaccineAssay for Transposase-Accessible Chromatin using sequencingAvidityBGPPBackBeta-TGBeta-galactosidase Protective ProteinBindingBinding DeterminantsBlood Plasma CellBlood Platelet Factor IVBlood PlateletsBlood monocyteBlood platelet factor 4Bone-Derived Transforming Growth FactorCD2 geneCD28CD28 geneCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCTAP IIICTAP3CTAPIIICTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCXC Chemokine Ligand 7CXCL7Cancer VaccinesCancersCarboxypeptidase YCathepsin ACell AggregationCell BodyCell CoatCell LineCell ProtectionCell-Mediated Lympholytic CellsCellLineCellsCheckpoint inhibitorChemokine (C-X-C motif) Ligand 4Chemokine Receptor GeneCitrobacterClinical TrialsColitisCollaborationsColonComplexConnective Tissue-Activating Peptide IIICross PresentationCytolytic T-CellCytoprotectionCytotoxic T CellCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneCytotoxic T-LymphocytesDNADataDeoxyribonucleic AcidDorsumDoseEdodekin AlfaEndosomesEndothelin Degradation EnzymeEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitopesExclusionFKHRFOXO1FOXO1AFOXO1A geneFactor 4FertilizationForkhead Box O1AForkhead in RhabdomyosarcomaFundingGI microbiotaGM-CSFGastrointestinal microbiotaGene ActivationGene TranscriptionGenesGenetic TranscriptionGlycocalyxGoalsGranulocyte-Macrophage Colony-Stimulating FactorGut MucosaHIVHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV InfectionsHIV env Protein gp120HIV vaccineHIV/AIDS VaccinesHIV/SIV vaccineHTLV-III InfectionsHTLV-III gp120HTLV-III-LAV InfectionsHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHeparin Neutralizing ProteinHistamine-Producing Cell-Stimulating FactorHistocompatibilityHomeHomingHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIFNIFN-GammaIFN-gIFN-γIFNGIFNγIL-12IL-15IL-17IL-17 GeneIL-17AIL-17A GeneIL12IL15IL15 ProteinIL17IL17 ProteinIL17 geneIL17AIL17A GeneIL21IgAImmuneImmune Cell ActivationImmune InterferonImmune checkpoint inhibitorImmune mediated therapyImmune responseImmunesImmunityImmunizationImmunodominant Antigenic DeterminantsImmunodominant DeterminantsImmunodominant DomainsImmunodominant EpitopesImmunodominant RegionsImmunodominant SitesImmunoglobulin AImmunologically Directed TherapyImmunologyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyInducer CellsInducer T-LymphocytesInfectionInnate ImmunityInterferon GammaInterferon Type IIInterferonsInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-12Interleukin-15Interleukin-15 PrecursorInterleukin-17KO miceKnock-out MiceKnockout MiceLA-PF4LAV-HTLV-IIILYT3Large Intestinal MucosaLarge IntestineLigandsLymphadenopathy-Associated VirusLysosomal Protective ProteinMGC9721MacacaMacaqueMalignant NeoplasmsMalignant TumorMarrow monocyteMarrow plateletMelanoma patientMemoryMiceMice MammalsMilk Growth FactorMiscellaneous AntibioticModern ManModificationMolecular InteractionMolgramostinMucosaMucosal ImmunityMucosal TissueMucous MembraneMurineMusMyeloid-derived suppressor cellsNAP-2NAP2NHP modelsNK T cellNKSFNKT cellNative ImmunityNatural ImmunityNatural Killer Cell Stimulatory FactorNatural Killer T cellNeoplasm VaccinesNeutrophil-Activating Peptide 2Non-Specific ImmunityNonspecific ImmunityNull MouseOVA-8OralPBP genePBP proteinPD 1PD-1PD-L1 antibodyPD1PF4 GenePPBPPPBP genePhasePlasma CellsPlasmablastPlasmacytesPlatelet Basic ProteinPlatelet Factor 4Platelet Transforming Growth FactorPlateletsPoxvirus officinalePredispositionPro-Platelet Basic ProteinProcessProductionProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqReceptosomesRecombinant Platelet Factor 4RectumRegulationRegulatory T-LymphocyteResearchRetinoic AcidRiskRoleSCYB4SCYB7SHIVSIINFEKL peptideSIVSIV VaccinesSRBCSTAT1STAT1 geneSTAT91SafetySerine Carboxypeptidase ISimian Immunodeficiency VirusesSiteSmall Inducible Cytokine B4Small Inducible Cytokine Subfamily B, Member 4Small Inducible Cytokine Subfamily B, Member 7Small IntestinesStomachStrains Cell LinesStructureSurfaceSusceptibilityT cell responseT-Cell DepletionT-CellsT-LymphocyteT-cell depletion therapyT-lymphocyte depletion therapyT11T4 CellsT4 LymphocytesT44T8 CellsT8 LymphocytesTC-GM-CSFTC1TC2TGB1TGF BTGF-betaTGF-βTGFbetaTGFβTLR proteinTLR3TLR3 geneTestingTextbooksThrombocidin 1Thrombocidin 2ThrombocytesThromboglobulin, Beta-1TimeTissue CompatibilityToll-Like Receptor 3Toll-Like Receptor Family GeneToll-like receptorsTrainingTrans Vitamin A AcidTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransgenic MiceTranslatingTranslationsTransmissionTregTretinoinTretinoinumTumor VaccinesTumor-Cell Human GM Colony-Stimulating FactorVaccine AdjuvantVaccine DesignVaccinesVaccinia virusVaginaViralViral AntigensViral BurdenViral DiseasesViral LoadViral Load resultVirusVirus DiseasesVirus-HIVVitamin A AcidWorkaPD-L1aPD-L1 antibodiesall-trans-Retinoic Acidall-trans-Vitamin A acidalumaluminum sulfateanti programmed cell death ligand 1anti programmed cell death protein ligand 1anti-PD-(L)1anti-PD-L1anti-PD-L1 antibodiesanti-PD-L1 monoclonal antibodiesanti-PDL-1anti-PDL1anti-PDL1 antibodiesanti-cancer immunotherapyanti-tumor vaccineantiPD-L1anticancer immunotherapyassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbasebasesbeta-Thromboglobulincancer immunotherapycarboxypeptidase Cchemokine receptorcultured cell linecytokinecytoprotectivedeliver vaccinesdesigndesigningenteric microbial communityenteric microbiotaepigeneticallyfertilizationsgamma-Thromboglobulingastricgastrointestinal microbial floragp120gp120 ENV Glycoproteingp120(HIV)gp160gut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahomeshost responsehuman immunodeficiency virus vaccineimmune activationimmune check point inhibitorimmune response to vaccinationimmune response to vaccinesimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive myeloid cellsimmunosuppressive responseimmunotherapy for cancerimmunotherapy of cancerimprintimprovedin vivointerleukin-21intestinal floraintestinal microbiotaintestinal microfloraintestinal tract microflorainventionkiller T celllFN-Gammalarge bowellymphoid structuresmalignancymicrobicidalmicrobicidemicrobiomemonocytemucosal vaccinemultiomicsmultiple omicsmyeloid suppressor cellsmyeloid-derived suppressive cellsnano particlenano particle deliverynano-sized particlenanoparticlenanoparticle deliverednanoparticle deliverynanosized particlenatural killer T lymphocyteneoplasm/cancernew approachesnonhuman primate modelsnovelnovel approachesnovel strategiesnovel strategypanomicspatients suffering from melanomapatients with melanomaplasmocyteplatelet factor IVpreventpreventingprogrammed cell death 1programmed cell death protein 1programmed death 1receptor expressionrecombinant vaccinia virusregulatory T-cellsresponsescRNA sequencingscRNA-seqsimian HIVsimian human immunodeficiency virussimian immunodeficiency virus vaccinessingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2small bowelsocial rolesuppressive myeloid cellssynergismsystemic lupus erythematosus susceptibility 2thymus derived lymphocytetraffickingtrans-Retinoic Acidtranscriptome sequencingtranscriptomic sequencingtranslationtransmission processvaccine associated immune responsevaccine deliveryvaccine efficacyvaccine for cancervaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine strategyvaginal mucosaviral detectionviral infectionviral transmissionvirus antigenvirus detectionvirus infectionvirus transmissionvirus-induced diseaseαPD-L1αPD-L1 antibodiesαPDL1β-TGβ-Thromboglobulin
Description preview
The strategies above involve several steps that together comprise a push-pull approach, to optimize antigen structure, improve quantity and quality of the response, and remove regulatory barriers. Blocking negative regulation in HIV and vaccine strategies: We carried out epitope enhancement (sequence modification to improve MHC binding) to…
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