grant
Vaccine and immunotherapy strategies for cancer and viruses causing cancer
Organization DIVISION OF CLINICAL SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025A2ARADORA2ADORA2A geneATAC sequencingATAC-seqATACseqAbscissionAdenosine A(2A) ReceptorAdenosine A2A ReceptorAdenosine ReceptorsAdenoviridaeAdenovirusesAdjuvantAffectAffinityAgonistAllogenicAnti-ERB-2Anti-HER2/c-erbB2 Monoclonal AntibodyAnti-c-ERB-2Anti-c-erbB2 Monoclonal AntibodyAnti-erbB-2Anti-erbB2 Monoclonal AntibodyAnti-p185-HER2AntibodiesAntigen PresentationAntigenic DeterminantsAntigensAntineoplastic VaccineAryl-sulfate sulfohydrolaseArylsulfatasesArylsulfate sulfohydrolasesAssay for Transposase-Accessible Chromatin using sequencingAutologousAvidityBeta-TGBindingBinding DeterminantsBiotechBiotechnologyBody TissuesBone-Derived Transforming Growth FactorBreast CancerBreast NeoplasmsBreast TumorsCD2 geneCD28CD28 geneCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCRADACTAP IIICTAP3CTAPIIICXC Chemokine Ligand 7CXCL7Cancer CauseCancer EtiologyCancer VaccinesCancersCell BodyCell ProtectionCell-Mediated Lympholytic CellsCellsCheckpoint inhibitorClinicalClinical TrialsCombination VaccinesCombined VaccinesCommon Rat StrainsComplexConnective Tissue-Activating Peptide IIICooperative Research and Development AgreementCytolytic T-CellCytoprotectionCytotoxic T CellCytotoxic T-LymphocytesDataDoseERBB2ERBB2 geneEarly-Stage Clinical TrialsEdodekin AlfaEndometrial CancerEndometrial CarcinomaEndometrium CancerEndometrium CarcinomaEndosomesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitopesEquilibriumEvaluableEvaluable DiseaseExcisionExpression SignatureExtirpationFKHRFLK1FOXO1FOXO1AFOXO1A geneFOXP3FOXP3 geneFailureForkhead Box O1AForkhead Box P3Forkhead in RhabdomyosarcomaGI microbiomeGM-CSFGene ActivationGene Expression ProfileGeneralized GrowthGlycolipidsGoalsGranulocyte-Macrophage Colony-Stimulating FactorGrowthHER -2HER-2HER2HER2 GenesHER2 Monoclonal AntibodyHER2/neuHLA Class I Histocompatibility Antigen, A-2 Alpha ChainHLA-A Class I Antigen 2HLA-A Histocompatibility Type Antigen 2HLA-A2HLA-A2 AntigenHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHerceptinHistamine-Producing Cell-Stimulating FactorHistocompatibilityHumanIL-12IL-13IL-15IL12IL13IL15IL15 ProteinImmune SurveillanceImmune checkpoint inhibitorImmune mediated therapyImmune responseImmunityImmunologic SurveillanceImmunologically Directed TherapyImmunologyImmunomodulationImmunosurveillanceImmunotherapyInducer CellsInducer T-LymphocytesInnate ImmunityInterleukin-12Interleukin-13Interleukin-15Interleukin-15 PrecursorJM2KDR geneKI miceKO miceKnock-in MouseKnock-out MiceKnockout MiceLA-PF4LigandsLipidsLungLung Respiratory SystemMGC9721Major Histocompatibility Complex, Class I, A2 AntigenMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMammary CancerMammary NeoplasmsMediatingMelanoma patientMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungMiceMice MammalsMilk Growth FactorMoAb HER2Modern ManModificationMolecular InteractionMolgramostinMucosaMucosal ImmunityMucosal TissueMucous MembraneMurineMusMyeloid CellsMyeloid-derived suppressor cellsN-3 polyunsaturated fatty acidNAP-2NAP2NEU OncogeneNEU proteinNK T cellNKSFNKT cellNative ImmunityNatural ImmunityNatural Killer Cell Stimulatory FactorNatural Killer T cellNeoplasm MetastasisNeoplasm VaccinesNeutrophil-Activating Peptide 2Non-Specific ImmunityNonspecific ImmunityNull MouseOmega-3 Fatty AcidsOmega-3 PUFAOmega-3 Polyunsaturated Fatty AcidOmega3Oncogene ErbB2P1 PurinoceptorsPBP genePBP proteinPD 1PD-1PD-1 antibodyPD-1 blockadePD-L1 antibodyPD-L1 blockadePD1PD1 antibodyPD1 blockadePDL1 blockadePPBPPPBP genePathway interactionsPatientsPeptidesPhasePhase 1 Clinical TrialsPhase 1/2 trialPhase I Clinical TrialsPhase I/II TrialPlatelet Basic ProteinPlatelet Transforming Growth FactorPrimary NeoplasmPrimary TumorPro-Platelet Basic ProteinProcessProstate CAProstate CancerProstate malignancyPublishingPurinergic P1 ReceptorsRDC8RatRats MammalsRattusReceptosomesRegulationRegulatory T-LymphocyteRemovalResearchRoleSCURFINSCYB7SRBCSafetySecondary NeoplasmSecondary TumorSkinSmall Inducible Cytokine Subfamily B, Member 7StimulantStructureSulfatidesSulfatoglycosphingolipidsSulfoglycosphingolipidsSurgical RemovalT cell responseT-Cell DepletionT-CellsT-LymphocyteT-cell depletion therapyT-lymphocyte depletion therapyT11T4 CellsT4 LymphocytesT44T8 CellsT8 LymphocytesTC-GM-CSFTC1TC2TGB1TGF BTGF-betaTGF-βTGFbetaTGFβTKR1TLR proteinTLR3TLR3 geneTM DomainTestingTherapeutic EffectThrombocidin 1Thrombocidin 2Thromboglobulin, Beta-1TimeTissue CompatibilityTissue GrowthTissuesToll-Like Receptor 3Toll-Like Receptor Family GeneToll-like receptorsTrainingTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransgenic MiceTranslatingTranslationsTransmembrane DomainTransmembrane RegionTrastuzumabTregTropismTumor AntigensTumor CellTumor ImmunityTumor PromotionTumor VaccinesTumor-Associated AntigenTumor-Cell Human GM Colony-Stimulating FactorVEGF ReceptorsVEGFRVEGFR-2VEGFR2VPF ReceptorVaccine AdjuvantVaccine DesignVaccineeVaccinesVascular Endothelial Cell Growth Factor ReceptorVascular Endothelial Growth Factor Receptor 2Vascular Permeability Factor ReceptorViral CancerViral DiseasesVirusVirus DiseasesWorkaPD-1aPD-L1aPD-L1 antibodiesaPD1acetyl-LDL receptoracetylated LDL receptoralpha-GalCeralpha-galactosylceramidealter microbiomeanaloganergyanti programmed cell death 1anti programmed cell death ligand 1anti programmed cell death protein ligand 1anti-PD-(L)1anti-PD-1anti-PD-1 Abanti-PD-1 antibodiesanti-PD-1 blockadeanti-PD-1 monoclonal antibodiesanti-PD-L1anti-PD-L1 antibodiesanti-PD-L1 blockadeanti-PD-L1 monoclonal antibodiesanti-PD1anti-PD1 Abanti-PD1 antibodiesanti-PD1 blockadeanti-PD1 monoclonal antibodiesanti-PDL-1anti-PDL1anti-PDL1 antibodiesanti-cancer immunotherapyanti-programmed cell death protein 1anti-programmed cell death protein 1 antibodiesanti-programmed death-1 antibodyanti-tumor immunityanti-tumor vaccineantiPD-1antiPD-L1anticancer immunotherapyantitumor immunityassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbalancebalance functionbeta-Thromboglobulinc-erb-2 Monoclonal Antibodyc-erbB-2c-erbB-2 Genesc-erbB-2 Proto-Oncogenescancer antigenscancer immunitycancer immunotherapycancer metastasiscell killingcytokinecytoprotectivedesigndesigningdigestive tract microbiomeenteric microbiomeepigeneticallyerbB-2 Genesextracellulargastrointestinal microbiomegene expression patterngene expression signaturegut microbiomegut-associated microbiomeherstatinhost responseimmune check point inhibitorimmune modulationimmune regulationimmune response to vaccinationimmune response to vaccinesimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive myeloid cellsimmunotherapy for cancerimmunotherapy of cancerimprovedinhibitorintestinal biomeintestinal microbiomeinventionkiller T cellknockin micelung metastasismalignancymalignant breast tumormammary tumormetastasize to the lungmicrobiomemicrobiome adaptationmicrobiome alterationmicrobiome perturbationmultiomicsmultiple omicsmyeloid suppressor cellsmyeloid-derived suppressive cellsn-3 Fatty Acidsn-3 PUFAnatural killer T lymphocyteneoplasm/cancerneoplastic cellneu Genesnew approachesnovelnovel approachesnovel strategiesnovel strategyomega-3omega-3sontogenypanomicspathwaypatients suffering from melanomapatients with melanomaphase 1 trialphase I protocolphase I trialpre-clinical studypreclinical studypreventpreventingprogrammed cell death 1programmed cell death protein 1programmed death 1pulmonary metastasisrecruitregulatory T-cellsresectionresponserhuMAb HER2scRNA sequencingscRNA-seqscavenger receptorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2social rolesuppressive myeloid cellssynergismsystemic lupus erythematosus susceptibility 2thymus derived lymphocytetranscriptional profiletranscriptional signaturetranslationtumortumor cell metastasistumor growthtumor-specific antigenvaccinated individualvaccinated participantvaccinated patientvaccinated personvaccinated subjectvaccine associated immune responsevaccine efficacyvaccine for cancervaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine strategyviral infectionviral transmissionvirus infectionvirus transmissionvirus-induced diseaseα-GalCerα-galactosylceramideαPD-1αPD-L1αPD-L1 antibodiesαPD1αPDL1β-TGβ-Thromboglobulin
Description preview
The strategies above involve 5 steps that comprise a push-pull approach, to optimize antigen structure, improve quantity and quality of the response, and remove regulatory barriers. Regulation of tumor immunity by NKT cells: NKT cells are true T cells recognizing glycolipid antigens presented by CD1d. We discovered a novel immunoregulatory pathway…
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