grant
Using proteomics to identify host cell death factors during M. tuberculosis infection
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 16 Jul 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AllelesAllelomorphsAlveolar MacrophagesAnimalsApoptosisApoptosis PathwayAssayAutophagocytosisAutophagosomeBinding ProteinsBioassayBiological AssayBone MarrowBone Marrow Reticuloendothelial SystemCell BodyCell Communication and SignalingCell DeathCell SignalingCellsData SetDevelopmentEngineeringEventFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2Funding OpportunitiesGeneralized GrowthGrowthHost DefenseHost FactorHost Factor ProteinHumanImmuneImmune responseImmunesInfectionInflammasomeInflammation MediatorsInflammatoryInflammatory ResponseIntegration Host FactorsIntracellular Communication and SignalingKinasesKnock-outKnockoutLigand Binding ProteinLigand Binding Protein GeneLoxP-flanked alleleM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacrophageMechanistic Target of RapamycinMembraneMiceMice MammalsModelingModern ManMurineMusMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNecrosisNecroticOutcomePathogenesisPathway interactionsPhosphoproteinsPhosphorylationPhosphotransferase GenePhosphotransferasesPositionPositioning AttributeProgrammed Cell DeathProtein BindingProtein PhosphorylationProteomeProteomicsPublic HealthPulmonary MacrophagesRAFT1Receptor ProteinRoleSignal TransductionSignal Transduction SystemsSignalingSystemTB infectionTB therapyTB treatmentTaxesTestingTissue GrowthTransphosphorylasesTreatment PeriodTreatment ProtocolsTreatment RegimenTreatment ScheduleTuberculosisautophagybiological signal transductionbound proteincell typeclinical developmentdevelop therapydevelopmentaldisseminated TBdisseminated tuberculosisfloxedfloxed alleleglobal healthhost responsehuman diseaseimmune system responseimmunoresponsein vivoin vivo Modelinfection due to Mycobacterium tuberculosisinflammatory mediatorinhibitorinnovateinnovationinnovativeintervention developmentmTORmammalian target of rapamycinmembrane structuremouse modelmtbmurine modelnecrocytosisnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypathogenpathwayphospho-proteomicsphosphoproteomicsprotein functionreceptorresponsesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapy developmenttreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistreatment daystreatment developmenttreatment durationtuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathy
Description preview
Abstract
Infections from M. tuberculosis (Mtb) are a persistent global health threat. To develop therapies that augment
protective host immune responses against Mtb and shorten TB treatment, this proposal seeks to test our
central hypothesis that Mtb infection triggers autophagy factor phosphorylation that regulates host cell death
mechanisms.…
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