grant
Using genetics to discover mechanisms of abdominal aortic aneurysm
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 18 Aug 2011Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAbdominal Aortic AneurysmAcademiaActive Follow-upAddressAdverse effectsAffectAnimal ModelAnimal Models and Related StudiesAortaApoptosisApoptosis PathwayAreaAssay for Transposase-Accessible Chromatin using sequencingAtrial FibrillationAuricular FibrillationBioinformaticsBiologicalBiologyBody TissuesCUT&RUNCandidate Disease GeneCandidate GeneCardiac infarctionCardiovascular DiseasesCausalityCause of DeathCell BodyCell Culture TechniquesCell NucleusCell ProtectionCell to Cell Communication and SignalingCell-Cell SignalingCellsCellular biologyChromatinChromosome MappingCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCo-ImmunoprecipitationsCollaborationsComplexComputer AnalysisCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCytoprotectionData SetDevelopmentDiagnosisDiagnosticDifferences between sexesDiffers between sexesDiglycolaldehydeDiseaseDisorderDrugsEarly DiagnosisElastasesElderlyEtiologyExtracellular Matrix DegradationFamilyFollow-Up StudiesFollowup StudiesFundingGWA studyGWASGene LocalizationGene MappingGene Mapping GeneticsGene TargetingGene variantGenesGeneticGenetic DiseasesGenetic studyGenomic SegmentGenomicsGoalsHeartHeritabilityHigh PrevalenceHistoryIdAIn VitroIndividualInflammationInosine DialdehydeInoxKI miceKnock-in MouseKnock-outKnockoutLeiomyocyteLinkLinkage MappingMapsMedical ResearchMedicationMendelian randomizationMeta-AnalysisMethodologyMiceMice MammalsModelingMultiomic DataMurineMusMyocardial InfarctMyocardial InfarctionNucleusOperative ProceduresOperative Surgical ProceduresOrgan DonorOxidative StressPathogenesisPathway interactionsPatient MonitoringPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlayPopulationPreventative treatmentPreventionPreventive treatmentProbabilityProgrammed Cell DeathProteinsPublicationsRNA SeqRNA sequencingRNAseqRecording of previous eventsRegulationReportingResearchRestRiskRisk FactorsRoleRuptureSample SizeSamplingScientific PublicationScientistSex DifferencesSexual differencesSmokerSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSurgicalSurgical InterventionsSurgical ProcedureSymptomsT cell factor 4T cell transcription factor 4T-Cell-Specific Transcription Factor 4TCF-4TCF4TCF7L2TCF7L2 geneTcf4 transcription factorTcf712 transcription factorTissuesTotal Human and Non-Human Gene MappingTranscription Factor 7-Like 2Transgenic MiceUnited StatesVariantVariationVascular Smooth Muscleabdominal aortaactive followupadvanced ageallelic variantassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingatherosclerotic coronary diseasebio-informatics toolbiobankbioinformatics toolbiologicbiorepositorycandidate identificationcardiac infarctcardiovascular disordercausal allelecausal genecausal mutationcausal variantcausationcausative mutationcausative variantcell biologycell culturecell culturescomputational analysescomputational analysiscomputer analysescoronary arterial diseasecoronary attackcoronary infarctcoronary infarctioncytoprotectivedevelopmentaldifferential expressiondifferentially expresseddiscover genesdisease causationdisease riskdisorder riskdrug/agentearly detectioneffective therapyeffective treatmentexperiencefollow upfollow-upfollowed upfollowupgain of functiongene discoverygene locusgenetic approachgenetic conditiongenetic disordergenetic locusgenetic mappinggenetic strategygenetic variantgenome segmentgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic locationgenomic locusgenomic regiongenomic variantgeriatrichealth care burdenheart attackheart infarctheart infarctionhistoriesin vivoinsightintercellular communicationinterestknockin miceloss of functionmalemodel of animalmouse modelmultiomicsmultiple omic datamultiple omicsmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpanomicspathwaypharmaceuticalphenomepopulation basedpower analysisresponsescATAC sequencingscATAC-seqscRNA sequencingscRNA-seqscreeningscreeningssenior citizensexsex based differencessex-dependent differencessex-related differencessex-specific differencessingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolestatisticssuccesssurgerytooltraittranscriptional differencestranscriptome sequencingtranscriptomic sequencingwhole genome association analysiswhole genome association study♂
Description preview
PROJECT SUMMARY/ABSTRACT
The goal of this R01 proposal is to advance our understanding of the genetic regulatory mechanisms
underlying the newly identified loci associated with abdominal aortic aneurysms (AAA), with the ultimate goal of
enabling earlier prevention and treatment of the disease. Our research team comprises individuals from
multiple…
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