grant
Using gene expression to identify patients at high risk for late breast cancer recurrence
Organization UNIVERSITY OF VERMONT & ST AGRIC COLLEGELocation BURLINGTON, UNITED STATESPosted 18 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025ASCOActive Follow-upAdjuvant TherapyAgeAgreementAmericanAmerican Society of Clinical OncologyAnti-estrogen TherapyApoptoticArchivesAssayAttentionBioassayBiologicalBiological AssayBiological MarkersBreast CancerBreast Cancer PatientBreast Cancer TreatmentBreast Cancer survivorBreast NeoplasmsBreast Tumor PatientBreast TumorsCalendarCell BodyCell Communication and SignalingCell DeathCell SignalingCell divisionCellsCharacteristicsClinicalClinical ManagementCohort StudiesCollectionConcurrent StudiesDataDiagnosisDiseaseDisorderDistantDrugsER PositiveER+EnsureEnvironmentEstrogen ReceptorsEstrogen receptor positiveExpression SignatureFaceFormalinGene ExpressionGene Expression ProfileGenesGenomicsGuidelinesHandHealthHigh Risk WomanHistoryHypoxiaHypoxicImmune SurveillanceImmunologic SurveillanceImmunosurveillanceIntracellular Communication and SignalingLeadLogistic RegressionsMalignant Breast NeoplasmMammary CancerMammary NeoplasmsMedical RecordsMedicationMenopausal StatusMenopauseMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorModelingMolecularMolecular EpidemiologyNCCNNational Comprehensive Cancer NetworkNeoplasm MetastasisNon-metastaticNonmetastaticOperative ProceduresOperative Surgical ProceduresOxygen DeficiencyParaffin EmbeddingPathologyPathway interactionsPatientsPatternPb elementPharmaceutical PreparationsPopulation StudyPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePre-MenopausePre-menopausal PeriodPredicting RiskPremenopausalPremenopausal PeriodPremenopausePrimary NeoplasmPrimary TumorProcessPrognostic MarkerProtacProteolysis targeting chimericProviderRecommendationRecording of previous eventsRecurrenceRecurrentRecurrent Malignant NeoplasmRecurrent Malignant TumorRegistriesReproducibilityRiskSamplingSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSpecificityStage at DiagnosisSurgicalSurgical InterventionsSurgical ProcedureTestingTimeToxic effectToxicitiesTumor TissueValidationWomanWorkactive followupadjuvant endocrine therapyadjuvant endocrine treatmentadjuvant treatmentafter menopauseagesantagonismantagonistassaultat-risk femalesat-risk womenbio-markersbiobankbiologicbiologic markerbiological signal transductionbiomarkerbiorepositorybreast cancer survivalcancer metastasiscancer recurrencecohortcomputer based predictiondemographicsdesigndesigningdifferential expressiondifferentially expresseddiscover genesdrug/agentevidence basefacesfacialfemales at high riskfollow upfollow-upfollowed upfollowing menopausefollowupforecasting riskgene discoverygene expression patterngene expression signatureglobal gene expressionglobal transcription profilehandsheavy metal Pbheavy metal leadhigh riskhigh risk femaleshistoriesimprovedindexingindividuals with breast cancermRNA Expressionmachine learned algorithmmachine learning algorithmmachine learning based algorithmmachine learning based modelmachine learning modelmalignant breast tumormammary tumormolecular diagnosticsnecrocytosisnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generationnext generation therapeuticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpast menopausepathwaypatients with breast cancerperson with breast cancerpopulation-based studypopulation-level studypost-menopausalpostmenopausalpostmenopausal statuspre-menopausalpredict riskpredict riskspredicted riskpredicted riskspredicting risksprediction algorithmpredictive modelingpredictive panelpredictive riskpredicts riskpremenopausal statuspreventpreventingprognosis modelprognostic assaysprognostic biomarkerprognostic indicatorprognostic modelprognostic testprophylacticproteolysis targeting chimaeraproteolysis targeting chimerarisk predictionrisk predictionsrisk stratificationscreeningscreeningsstratify riskstudies of populationsstudy of the populationsurgerytranscriptional differencestranscriptional profiletranscriptional signaturetranscriptometreatment adherencetreatment compliancetreatment strategytumortumor cell metastasisvalidationswomen at high risk
Description preview
PROJECT SUMMARY
Non-metastatic breast cancer is treated surgically and with adjuvant therapies. As these treatments have
improved, recurrence-free survival has steadily increased, and late recurrence (recurrence beyond 10 years’
survival) has become a pressing issue for patients and providers. There are existing and emerging therapies
that…
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