grant
Using a Health Disparity Research Framework to examine mechanisms linking Obstructive Sleep Apnea with higher Alzheimer’s disease risk in older Blacks/African-Americans
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Jun 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025(TNF)-αAD dementiaAD pathologyAD preventionAD related dementiaADRDAPOEActive Follow-upAddressAffectAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAmyloidAmyloid SubstanceApo-EApoE proteinApolipoprotein EAreaAβ burdenB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBMIBMI percentileBMI z-scoreBSF-2BSF2BehavioralBlackBlack PopulationsBlack groupBlack individualBlack peopleBlack raceBlacksBlood PlasmaBlood VesselsBody mass indexBrainBrain Nervous SystemCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCachectinCerebrospinal FluidClinicalClinical EvaluationClinical TestingCognitionCognitiveCognitive DiscriminationCommunitiesCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDelta WaveDelta Wave sleepDiabetes MellitusDiscriminationDiseaseDisease OutcomeDisorderEconomic IncomeEconomical IncomeEducationEducational aspectsEligibilityEligibility DeterminationEncephalonEnrollmentEntorhinal AreaEthnic OriginEthnicityExcessive Daytime SleepinessExcessive daytime somnolenceExhibitsFoundationsFutureHPGFHealth Disparities ResearchHealth disparities related researchHepatocyte-Stimulating FactorHeterogeneityHigh PrevalenceHomeHybridoma Growth FactorHypertensionIFN-beta 2IFNB2IL-17IL-17 GeneIL-17AIL-17A GeneIL-6IL17IL17 ProteinIL17 geneIL17AIL17A GeneIL6 ProteinIncomeInferiorInflammationInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17Interleukin-6InvestigationKnowledgeLaboratoriesLesionLinkMGI-2MR ImagingMR TomographyMRIMRIsMT-bound tauMacrophage-Derived TNFMagnetic Resonance ImagingMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMonocyte-Derived TNFMyeloid Differentiation-Inducing ProteinNMR ImagingNMR TomographyNREMNational Institutes of HealthNerve DegenerationNeuron DegenerationNeuropsychologic TestsNeuropsychological TestsNewly DiagnosedNon-HispanicNonhispanicNot Hispanic or LatinoNuclear Magnetic Resonance ImagingObstructive Sleep ApneaOlder PopulationOnset of illnessPETPET ScanPET imagingPETSCANPETTParticipantPathologicPathologyPatient CarePatient Care DeliveryPlasmaPlasma SerumPlasmacytoma Growth FactorPolysomnographyPopulation HeterogeneityPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProtocol ScreeningPublic HealthPublic Health PracticeQuetelet indexRaceRacesRad.-PETResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRisk FactorsSamplingScienceSeveritiesSleepSleep MonitoringSlow-Wave SleepSocio-economic statusSocioeconomic StatusSomnographyStressSurrogate MarkersSyndrome, Sleep Apnea, ObstructiveTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTauopathiesTemporal LobeTestingThickThicknessTumor Necrosis FactorTumor Necrosis Factor-alphaUnited States National Institutes of HealthVascular Hypertensive DiseaseVascular Hypertensive DisorderVisitWorkZeugmatographya-beta burdenabeta burdenactigraphactigraphyactive followupagesallostatic loadalzheimer riskamyloid burdenamyloid pathologybeta amyloid burdencardiovascular riskcardiovascular risk factorcare for patientscare of patientscaring for patientscerebral spinal fluidclinical testcohortdeprivationdiabetesdifferences due to racedifferences in racediffers by racediffers in racedisease disparitydisease modeldisease onsetdisorder modeldisorder onsetdiverse populationsenrollentorhinal cortexfollow upfollow-upfollowed upfollowuphealth datahealth disparities scienceheterogeneous populationhigh blood pressurehomeshyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedin vivoincomesindexinginnovateinnovationinnovativeinterferon beta 2intervention designlate in lifelate lifemicrotubule bound taumicrotubule-bound tauneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropathologic tauneuropathological taunew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetolder adultolder adulthoodolder groupsolder individualsolder personp-taup-τperceived stressperception of stressphospho-tauphospho-τphosphorylated taupopulation diversitypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of tauposttranslational modification of tauprimary degenerative dementiaquality of sleeprace based differencesrace differencesrace related differencesracialracial backgroundracial differenceracial originracially differentrecruitresearch clinical testingself-reported stresssenile dementia of the Alzheimer typesexsleep controlsleep measurementsleep polysomnographysleep qualitysleep regulationsleep/wake regulationsocialsocial structuralsocial structuresocio-economic positionsocio-structuralsocioeconomic positionsociostructuralspinal fluidstress bufferingstress managementstress perceptionstructural health determinantssubstantia albasurrogate bio-markerssurrogate biomarkerstautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathytemporal cortextherapy designtooltreatment designuptakevascularvascular risk factorwhite matterβ-amyloid burdenβamyloid burdenτ Proteinsτ phosphorylation
Description preview
PROJECT ABSTRACT/SUMMARY
Blacks/African-Americans (blacks) have two times the risk of developing Alzheimer’s disease (AD) compared to
non-Hispanic whites (whites), in part attributable to the higher prevalence of vascular risk factors. Examining
other risk factors and delineating pathological mechanisms associated with this higher AD-risk in older…
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