grant
Use of lentivirus in individualized cell-gene therapy
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Annual ReportsApheresisAutologousBlood Component RemovalCell BodyCell CountCell NumberCellsCentrifugationCentrifugation FractionationClinicalDNA TherapyExperimental DesignsFutureGene Transfer ClinicalGenetic InterventionHemapheresisHistoryLentivirinaeLentivirusMaintenanceMemoryOlder PopulationOperative ProceduresOperative Surgical ProceduresPatientsPhenotypePheresisPopulationProcessProductionProliferatingProtocolProtocols documentationReagentRecording of previous eventsReportingRetroviral VectorRetroviridaeRetrovirus VectorRetrovirusesStem Cell likeSurgicalSurgical InterventionsSurgical ProcedureSystemT-Cell ActivationT-CellsT-LymphocyteTestingTherapeuticTimeTransfectionUndifferentiatedViral VectorVirusVirus-RetrovirusWorkactivate T cellscell transductioncellular transductioncytokineexhaustgene repair therapygene therapygene-based therapygenetic therapygenomic therapyhistoriesimprovedmanufacturemanufacturing processolder groupsolder individualsolder personprecision medicineprecision-based medicinepreservationprogenitor capacityprogenitor cell likeprogenitor-likestem cell characteristicsstem-likestemnesssurgerythymus derived lymphocytetimelinetransduced cellstransduction efficiencyvector
Description preview
AIM 1 This successful completion of this aim has been reported in the previous year's annual reports. AIM 2 During this reporting period, a cell production pipeline utilizing lentivirus that reduced manufacturing time and preserved/augmented a greater percentage of undifferentiated T cells (phenotype) was developed. Variables that were tested and…
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